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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
The data is from an SDS, issued by the manufacturer.

Data source

Reference
Reference Type:
publication
Title:
Hygiene of labour
Author:
Zaugliikov S. D., Predtechenskiy M. B
Year:
1967
Bibliographic source:
Not specified

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data available.
GLP compliance:
not specified
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl nitrate
EC Number:
216-983-6
EC Name:
Isopropyl nitrate
Cas Number:
1712-64-7
Molecular formula:
C3H7NO3
IUPAC Name:
propan-2-yl nitrate
Test material form:
liquid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
ca. 2 h
Concentrations:
6 mg/l
No. of animals per sex per dose:
Not available
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
ca. 29 000 mg/m³ air
Based on:
test mat.
Exp. duration:
2 h

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The Isopropyl nitrate affects the central nervous system of the tested species, causes lack of coordination and formation of methemoglobin.