Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
The data is from an SDS, issued by the manufacturer.

Data source

Reference
Reference Type:
publication
Title:
Hygiene of labour
Author:
Zaugliikov S. D., Predtechenskiy M. B
Year:
1967
Bibliographic source:
Not specified

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data available.
GLP compliance:
not specified
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl nitrate
EC Number:
216-983-6
EC Name:
Isopropyl nitrate
Cas Number:
1712-64-7
Molecular formula:
C3H7NO3
IUPAC Name:
propan-2-yl nitrate
Test material form:
liquid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
ca. 2 h
Concentrations:
6 mg/l
No. of animals per sex per dose:
Not available
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
ca. 29 000 mg/m³ air
Based on:
test mat.
Exp. duration:
2 h

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The Isopropyl nitrate affects the central nervous system of the tested species, causes lack of coordination and formation of methemoglobin.