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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 Oct 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Qualifier:
according to
Guideline:
other: Collaborative International Pesticides Analytical Council Limited, England, CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”. In: CIPAC Handbook, Vol. K, “Analysis of Technical and Formulated Pesticides”
Version / remarks:
2003
Principles of method if other than guideline:
MT 187 - Particle size analysis by laser diffraction

Outline of method
A representative sample, dispersed at an adequate concentration in a suitable liquid or gas, is passed through the beam of a monochromatic light source, usually a laser. The light scattered by the particles at various angles is measured by a multi-element detector and numerical values relating to the scattering pattern are then recorded for subsequent analysis. These numerical scattering values are then transformed, using an appropriate optical model and mathematical procedure, to yield the proportion of total volume to a discrete number of size classes forming a volumetric particle size distribution.

Scope
This method provides guidance on the measurement of particle size distributions of crop protection formulations, for example granules, powders, suspensions and emulsions, through analysis of their angular light scattering patterns. Detailed descriptions for the use of laser diffraction methods are given in ISO 13320-1.

Reference
http://cipac.org/index.php/p4/442-mt-187-particle-size-analysis-by-laser-diffraction
GLP compliance:
yes
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Percentile:
D10
Mean:
5.991 µm
St. dev.:
0.299
Percentile:
D50
Mean:
20.1 µm
St. dev.:
0.483
Percentile:
D90
Mean:
136 µm
St. dev.:
9.188

Particle Size Analysis by Laser Diffraction

Replication

Particle Size (μm)

d(0.1) [10%] μm

d(0.5) [50%] μm

d(0.9) [90%] μm

R1

5.667

19.54

125.5

R2

6.048

20.40

142.4

R3

6.257

20.35

140.2

Mean ± SD*

5.991 ± 0.299

20.10 ± 0.483

136.0 ± 9.188

 

Particle Sizes Above 50 μm by Laser Diffraction

Diameter

%

(μm)

Replication 1

Replication 2

Replication 3

52.63

1.14

1.15

1.18

57.77

1.03

1.06

1.14

63.42

1.02

1.07

1.18

69.62

1.09

1.13

1.25

76.43

1.18

1.21

1.31

83.9

1.23

1.24

1.28

92.1

1.19

1.21

1.16

101.1

1.09

1.14

0.99

111

1.01

1.09

0.85

121.8

1.04

1.11

0.83

133.7

1.22

1.22

0.96

146.8

1.50

1.41

1.26

161.2

1.75

1.61

1.60

176.9

1.77

1.72

1.83

194.2

1.49

1.66

1.80

213.2

0.97

1.41

1.47

234.1

0.45

1.00

0.95

256.9

0.12

0.54

0.45

282.1

0.016

0.20

0.13

309.6

0.00048

0.037

0.019

339.9

0

0.0028

0.00086

Total

20.3

22.2

21.6

Mean ± SD*

21.4 ± 1.0

 

* Mean and Standard Deviation were calculated using Microsoft Excel 2010 software.

Description of key information

Standard protocol, GLP-compliant study available. Partcicle size was determined using laser diffraction method. D50 was 20.1um.

Additional information