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EC number: 205-766-1
CAS number: 150-68-5
In a two-generation reproduction
study, rats (P, 30/sex/dose) received 0, 10, 250 or 1750 ppm of diuron
in the daily diet for 73 days, and then bred within the dose groups to
produce F1 litters. At weaning on Day 21, 30 F1 rats/sex/dose were
randomly selected, and at least 105 days after weaning, the F1 rats were
bred to produce F2 litters. For both generations, administration of the
test substance continued during breeding, gestation and lactation.
During premating the calculated daily intakes of diuron for both
generations were as follows: for males an average of 0.68, 16.9, and 120
mg/kg/day and for females an average of 0.80, 20.3, and 144 mg/kg/day.
Compound-related parental toxicity was
observed at 1750 ppm as evidenced by decreased body weight, body weight
gain, and food consumption in both sexes and generations. The NOEL and
LOEL for parental toxicity were 250 and 1750 ppm, respectively.
Compound-related reproductive toxicity
was observed at 1750 ppm as evidenced by decreased pup body weight
during the lactation period for both sexes and generations. The NOEL and
LOEL for reproductive toxicity were 250 and 1750 ppm, respectively.
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