Registration Dossier
Registration Dossier
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EC number: 205-766-1 | CAS number: 150-68-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1955
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Report on Monuron, EPA Pesticide Petition
- Author:
- Zapp, J.A.
- Year:
- 1 955
- Bibliographic source:
- EPA Pesticide Petition, n17, vol II
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Monuron
- EC Number:
- 205-766-1
- EC Name:
- Monuron
- Cas Number:
- 150-68-5
- Molecular formula:
- C9H11ClN2O
- IUPAC Name:
- 1-(4-chlorophenyl)-3,3-dimethylurea
1
- Specific details on test material used for the study:
- FORM AS APPLIED IN THE TEST 33% water paste
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male
Study design: in vivo (non-LLNA)
Challenge
- Route:
- other: intact and abraded skin
- Vehicle:
- water
- Adequacy of challenge:
- not specified
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Group:
- test chemical
- Dose level:
- 33%
- Remarks on result:
- other: no details available
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The compound was practically nonirritanting an did not cause allergic skin.
- Executive summary:
This guinea pig study was carried out to evaluate the Primary Irritation and Skin Sensitization of Monuron. A 33% water paste of monuron was applied to both intact and abraded skin of male albino guinea pigs. The compound was practically non irritating and did not cause allergic skin sensitization. No further details were given on such parameters as numbers used or period of experimentation. The author concluded that a moderate amount of skin contact with Monuron would not be harmful because it is not an irritant or a sensitizer, nor is it significantly absorbed through the skin (Zapp, 1955) .
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