Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
no method provided
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Mugil cephalus
Test type:
not specified
Water media type:
not specified
Remarks:
Most likely saltwater sine this is a marine species
Total exposure duration:
48 h
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
16.3 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
not specified
Conclusions:
Mugil cephalus 48-h LC50: 16.3 mg/L
Executive summary:

According to Butler (1965; cited in US-EPA document EPA-504 -1 -75 -028 ; 1975, page 53) Monuron has an acute toxicity (48 -h LC50) to striped mullet (Mugil cephalus) of 16.3 mg/L

Further details were not reported. Since this information is obtained form a peer reviewed document from an international accepted authority the result is considered reliable with restrictions for the further assessment.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
no method provided
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Coho salmon; channel catfish, largemouth bass, smallmouth bass, bluegill, green sunfish, brown sunfish, carp, fathead minnow, Sacramento squawfish and golden shiner
Details on test organisms:
Data for a variety of fish species is reported
Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h
Remarks on result:
other: Results are provided under "Details on results"
Details on results:
In the report following statement is made:

"Lawrence (1964) has summarized the 48-hr effect of monuron on fish; Coho salmon survived 110 ppm; channel catfish survived 39.8 ppm; largemouth bass, smallmouth bass, bluegill, green sunfish, brown sunfish, carp, fathead minnow, Sacramento squawfish and golden shiner all survived 32 ppm".
Validity criteria fulfilled:
not specified
Conclusions:
Oncorhynchus mykiss 48-h LC50: 80 mg/L
Executive summary:

In the report following statement is made:

"Lawrence (1964) has summarized the 48-hr effect of monuron on fish; Coho salmon survived 110 ppm; channel catfish survived 39.8 ppm; largemouth bass, smallmouth bass, bluegill, green sunfish, brown sunfish, carp, fathead minnow, Sacramento squawfish and golden shiner all survived 32 ppm".

Further details were not reported. Since this information is obtained form a peer reviewed document from an international accepted authority the result is considered reliable with restrictions for the further assessment.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
no method provided
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Oncorhynchus kisutch
Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
110 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
not specified
Conclusions:
Oncorhynchus kisutch 48-h LC50: 110 mg/L
Executive summary:

The acute 48-h toxicity of Monuron to Oncorhynchus kisutch was reported to be 110 mg/L (LC50).

Further details were not reported. Since this information is obtained form a peer reviewed document from an international accepted authority the result is considered reliable with restrictions for the further assessment.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
no method provided
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
100 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
80 mg/L
Nominal / measured:
not specified
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
not specified
Conclusions:
Oncorhynchus mykiss 48-h LC50: 80 mg/L
Executive summary:

According to Alabaster (1969; cited in US-EPA document EPA-504 -1 -75 -028 ; 1975, page 53) Monuron has an acute toxicity (48 -h LC50) to rainbow trout (Oncorhynchus mykiss) of 80 mg/L (100 mg/L for the 80% formulation).

Further details were not reported. Since this information is obtained form a peer reviewed document from an international accepted authority the result is considered reliable with restrictions for the further assessment.

Description of key information

The lowest 48 -hour LC50 for marine and freshwater species was 16.3 mg/L (Mugil cephalus).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
16.3 mg/L

Additional information

There is several data on the short term toxicity to fish from reports from authorities for freshwater and marine fish. All data are for 48 hour exposure. The lowest 48 -hour LC50 was 16.3 mg/L ( Mugil cephalus). Further 48-hour LC50 data were > 32 mg/L for 10 freshwater fish species ( Coho salmon; channel catfish, largemouth bass, smallmouth bass, bluegill, green sunfish, brown sunfish, carp, fathead minnow, Sacramento squawfish and golden shiner) and 110 mg/L for Oncorhynchus kisutch. Experimental details were not reported for these studies. Since these data are obtained form peer reviewed documents prepared by international accepted authorities the results are considered reliable with restrictions for the further assessment.

These data were used for the WoE approach. The lowest reported LC50 value is 16.3mg/L. This value indicates that fish are orders of magnitude less sensitive than algae. It is considered scientifically unlikely that a prolongation of the exposure of the fish from 48 hours to 96 hours will lower the LC50 to values which will make fish more sensitive than algae. Therefore, the 48 -hour data are considered to be sufficiently relevant for the further assessment.

Since various freshwater and marine species were investigated the lowest 48-hour LC50 value is considered to be sufficiently conservative and a further factor for considering a factor for the "prolongation of exposure" to 96 hours is not needed.