Monuron

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Biodegradability was estimated using the BIOWIN™ v4.10 module of EPI Suite™ v.4.11. BIOWIN™ estimates aerobic and anaerobic biodegradability of organic chemicals using 7 different models. Two of these are the original Biodegradation Probability Program (BPP™).

Data source

Reference

Reference Type:

other: Result of QSAR calculations

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Biodegradation was estimated using the BIOWIN™ v4.10 module of EPI Suite™ v.4.11. BIOWIN™ estimates aerobic and anaerobic biodegradability of organic chemicals using 7 different models. Two of these are the original Biodegradation Probability Program (BPP™). The seventh and newest model estimates anaerobic biodegradation potential. The Estimation Programs Interface EPI Suite™ was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC).

Test material

Test material information

1

Reference substance name:

Monuron

EC Number:

205-766-1

EC Name:

Monuron

Cas Number:

150-68-5

Molecular formula:

C9H11ClN2O

IUPAC Name:

1-(4-chlorophenyl)-3,3-dimethylurea

Results and discussion

% Degradation

Key result

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Applicant's summary and conclusion

Conclusions:

The substance is considered not readily biodegradable

Executive summary:

Probability of Rapid Biodegradation (BIOWIN v4.10):

Biowin1 (Linear Model)        :  0.4706

Biowin2 (Non-Linear Model)    :  0.1385

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model):  2.5536 (weeks-months)

Biowin4 (Primary Survey Model) :  3.3958 (days-weeks )

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model)   :  0.1610

Biowin6 (MITI Non-Linear Model):  0.0517

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): -0.1071

Ready Biodegradability Prediction:  NO