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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Biodegradability was estimated using the BIOWIN™ v4.10 module of EPI Suite™ v.4.11. BIOWIN™ estimates aerobic and anaerobic biodegradability of organic chemicals using 7 different models. Two of these are the original Biodegradation Probability Program (BPP™).

Data source

Reference
Reference Type:
other: Result of QSAR calculations
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Biodegradation was estimated using the BIOWIN™ v4.10 module of EPI Suite™ v.4.11. BIOWIN™ estimates aerobic and anaerobic biodegradability of organic chemicals using 7 different models. Two of these are the original Biodegradation Probability Program (BPP™). The seventh and newest model estimates anaerobic biodegradation potential. The Estimation Programs Interface EPI Suite™ was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC).

Test material

1
Chemical structure
Reference substance name:
Monuron
EC Number:
205-766-1
EC Name:
Monuron
Cas Number:
150-68-5
Molecular formula:
C9H11ClN2O
IUPAC Name:
1-(4-chlorophenyl)-3,3-dimethylurea

Results and discussion

% Degradation
Key result
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction

Applicant's summary and conclusion

Conclusions:
The substance is considered not readily biodegradable
Executive summary:

Probability of Rapid Biodegradation (BIOWIN v4.10):

Biowin1 (Linear Model)        :  0.4706

Biowin2 (Non-Linear Model)    :  0.1385

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model):  2.5536 (weeks-months)

Biowin4 (Primary Survey Model) :  3.3958 (days-weeks )

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model)   :  0.1610

Biowin6 (MITI Non-Linear Model):  0.0517

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): -0.1071

Ready Biodegradability Prediction:  NO