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Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Biodegradability was estimated using the BIOWIN™ v4.10 module of EPI Suite™ v.4.11. BIOWIN™ estimates aerobic and anaerobic biodegradability of organic chemicals using 7 different models. Two of these are the original Biodegradation Probability Program (BPP™).

Data source

Reference
Reference Type:
other: Result of QSAR calculations
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Biodegradation was estimated using the BIOWIN™ v4.10 module of EPI Suite™ v.4.11. BIOWIN™ estimates aerobic and anaerobic biodegradability of organic chemicals using 7 different models. Two of these are the original Biodegradation Probability Program (BPP™). The seventh and newest model estimates anaerobic biodegradation potential. The Estimation Programs Interface EPI Suite™ was developed by the US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC).

Test material

1
Chemical structure
Reference substance name:
Monuron
EC Number:
205-766-1
EC Name:
Monuron
Cas Number:
150-68-5
Molecular formula:
C9H11ClN2O
IUPAC Name:
1-(4-chlorophenyl)-3,3-dimethylurea

Results and discussion

% Degradation
Key result
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction

Applicant's summary and conclusion

Conclusions:
The substance is considered not readily biodegradable
Executive summary:

Probability of Rapid Biodegradation (BIOWIN v4.10):

Biowin1 (Linear Model)        :  0.4706

Biowin2 (Non-Linear Model)    :  0.1385

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model):  2.5536 (weeks-months)

Biowin4 (Primary Survey Model) :  3.3958 (days-weeks )

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model)   :  0.1610

Biowin6 (MITI Non-Linear Model):  0.0517

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): -0.1071

Ready Biodegradability Prediction:  NO