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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
according to
Guideline:
other: Modified flask method based on Method A.6 Water solubility of Commission Regulation (EC) No 440/2008 and Method 105 of the OECD Guidelines for Testing od Chemicals
GLP compliance:
yes (incl. certificate)
Key result
Medium:
n-octanol
Solubility:
>= 52.9 - <= 54.9 other: % w/w
Temp.:
20 °C
Medium:
n-octanol
Solubility:
>= 529 - <= 549 g/L
Temp.:
20 °C
Remarks on result:
other: assuming a relative density of ~1 for saturated solution in n-octanol

The sample concentrations and observations are shown in the following table:

Sample

Conc. (% w/w)

Observations

1

24.9%

Clear yellow liquid

2

27.4%

Clear yellow liquid

3

29.1%

Clear yellow liquid

4

31.0%

Clear yellow liquid, slightly more viscous than sample 3

5

33.1%

Clear yellow liquid, slightly more viscous than sample 4

6

34.9%

Clear yellow liquid, slightly more viscous than sample 5

7

34.8%

Amber colored liquid

8

37.1%

Amber colored liquid, slightly more viscous than sample 7

9

39.0%

Amber colored liquid, slightly more viscous than sample 8

10

40.9%

Amber colored liquid, slightly more viscous than sample 9

11

42.9%

Amber colored liquid, slightly more viscous than sample 10

12

45.0%

Amber colored liquid, slightly more viscous than sample 11

13

45.0%

Amber transparent liquid

14

46.9%

Amber transparent liquid, slightly more viscous than sample 13

15

48.9%

Amber transparent liquid, slightly more viscous than sample 14

16

50.9%

Amber transparent liquid, slightly more viscous than sample 15

17

52.9%

Amber transparent liquid, slightly more viscous than sample 16

18

54.9%

Amber transparent liquid with and amber solid / gel at the bottom

Conclusions:
The solubility of the test item in n-octanol has been determined to be in the range 52.9 to 54.9% w/w at 20.0 ±0.5 °C.
Executive summary:

The determination of the octanol solubility of the test item was carried out by visual assessment, using a modified flask method based on Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The standard flask shake method was not applicable to this test item due to the high saturation level. A range of sample concentrations were prepared to visually assess the point at which saturation was reached.

The solubility of the test item in n-octanol has been determined to be in the range 52.9 to 54.9% w/w at 20.0 ±0.5 °C.

Description of key information

The determination of the octanol solubility of the test item was carried out by visual assessment, using a modified flask method based on Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The standard flask shake method was not applicable to this test item due to the high saturation level. A range of sample concentrations were prepared to visually assess the point at which saturation was reached.

The solubility of the test item in n-octanol has been determined to be in the range 52.9 to 54.9% w/w at 20.0 ±0.5 °C.

Key value for chemical safety assessment

Additional information