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EC number: 214-014-1 | CAS number: 1072-71-5
In a dermal sensitization study (performed scientifically reasonable similar OECD TG 406) with unchanged 1,3,4-Thiadiazole-2,5-dithiole in 300-400 g albino guinea pigs (5/sex) were tested using the method of Bühler, irritation scoring according to Draize.
A 0.5 gm portion of material was applied to the intact skin test sites on the guinea pigs. After a 24 hour contact period (occlusive) the patch was removed and the animals were allowed to rest for one day. Exposure was repeated 10 times. After the tenth application the animals were rested for a two week period. At the termination of the rest period a challenge application was put on skin sites differing from the original test sites. The challenge application remained on for 24 hours. Twenty-four hours after each induction stage application and twenty-four and forty-eight hours after the challenge (re-test) application, the sites were examined for irritation, if any.
In none of the animals any sign of systemic toxicity, irritation or sensitization was noted after any application.
In this study, 1,3,4-Thiadiazole-2,5-dithiole is not a dermal sensitizer, no classification is required.
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