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EC number: 214-014-1 | CAS number: 1072-71-5
The study was performed to assess the acute dermal toxicity of the test item in the Wistar strain rat according to OECD TG 402 under GLP.
Methods: Initially, one female animal was given a single, 24 hour, semi‑occluded dermal application of the undiluted test item to intact skin at a dose level of 2000 mg/kg body weight. Based on the results of the initial test, a further two female animals were similarly treated. Clinical signs and body weight development were monitored during the study. All animals were subjected to gross necropsy.
Mortality. There were no deaths.
Clinical Observations. There were no signs of systemic toxicity.
Dermal Irritation. Signs of dermal irritation noted included very slight to well defined erythema and very slight edema. Crust formation, small superficial scattered scabs and scab lifting to reveal glossy skin were also noted. Yellow staining of the treatment sites was also noted.
Body Weight. One animal showed body weight loss during the first week with expected gain in body weight during the second week. The remaining animals showed expected gains in body weight.
Necropsy. No abnormalities were noted at necropsy.
Conclusion: The acute dermal median lethal dose (LD50) of the test item in the female Wistar strain rat was found to be greater than 2000 mg/kg body weight.
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