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EC number: 214-014-1 | CAS number: 1072-71-5
2,5-Dimercapto-1,3,4-thiadiazole (“DMTD”) was tested for acute toxicity towards fish according to OECD Guideline No.203 (1992) under GLP using zebra fish. In order to investigate the influence of the test item towards the fish, the animals were exposed to up to 100 mg of the test item per litre of test solution. Under the conditions used for the test, no significant toxic effects of the test item towards fish were observed at 100 mg/L (main test, performed as a limit test). As a conclusion of the analytical part of this study, it can be stated that the concentrations of 2,5-Dimercapto-1,3,4-thiadiazole (“DMTD”) remained sufficiently stable during incubation. Based on this, the reported effect concentrations should refer to the nominal concentrations tested. The following LC-values (effective concentrations) were determined accordingly:
On the Basis of the Nominal Concentrations [mg/L]
95%-CL lower n.d.
Mortality LOEC >100
NOEC ≥ 100
The criteria of validity of results given by the OECD Guideline 203 were kept within this study. In the control no dead animals were observed. In the test solutions the oxygen concentration did not drop below a value of 60% of the saturation value (»5 mg O2/L).
Short-term toxicity to fish: LC50 (96h) > 100 mg/L, LC0 (96h) ≥ 100 mg/L, NOEC (96h) ≥ 100 mg/L for rainbow trout (Oncorhynchus mykiss) (OECD 203, static)
There is a Klimisch 1 OECD 203 (rainbow trout over 96h) study available, indicating that the test item does not need to be classified as hazardous to the aquatic environment, neither acute nor chronic, according to Regulation (EC) No 1272/2008 and amendments. In this study, the results were LC50 (96h) > 100 mg/L, LC0 (96h) ≥ 100 mg/L, and NOEC (96h) ≥ 100 mg/L. There is no indication given that this data is not relevant for the assessment of ecotoxicological properties of DMTD. Hence, no data gap was identified, and the key value of LC50 = 100 mg/L, can be chosen for further risk assessment, although it must be noted that the actual LC50 is expected to be higher and the value was only stated as such due to limitations in the IUCLID entry field.
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