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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-01-11 - 2018-02-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
13-Apr-04
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material:
sponsor

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
At ambient temperature
- Stability under test conditions:
The test item is hydrolytically stable according to OECD 111 tier 1.
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
< 0
Temp.:
50 °C
Remarks on result:
not determinable
Conclusions:
The GLP study was performed according to OECD TG 117 without any deviations on the substance to be registered itself, the results were so obtained via a scientifically reasonable method. Hence, there is no doubt that the obtained results are not reliable: A determination of a partition coefficient (n-octanol/water) with the OECD 117 was not possible. Due to the fact that the test item has a retention before the dead time marker the OECD 117 is not valid to determine the log Pow of the test item.
The OECD 117 shows that the log Pow of the test item is < 0.0.
Executive summary:

The test item 2,5-Dimercapto-1,3,4-thiadiazole (“DMTD”) was tested according to OECD-Guideline 117 with the “HPLC-Method” under GLP. According to the definition of the OECD-Guideline 117 the test item shows a log Pow < 0.0. A more precise determination of the log Pow of the test item was not possible.

Description of key information

Partition coefficient: logPow <0.0 (HPLC method, OECD 117, GLP)

Key value for chemical safety assessment

Log Kow (Log Pow):
0
at the temperature of:
50 °C

Additional information