Reaction product of Hexamethylene diisocyanate, oligomers with Mercaptopropyltrimethoxysilane

Endpoint summary

Description of key information

Short-term toxicity to fish:

In a 96-hour static acute toxicity test on Zebrafish (Brachydanio rerio) an LC50 value of > 100 mg/L and a NOEC of 100 mg/L were determined.

 

Short-term toxicity to daphnia:

In an acute toxicity study with Daphnia magna an 48-h EC50 value of >100 mg/L and a NOEC of 100 mg/L was determined.

 

Short-term toxicity to algae:

In a 72-h algal growth inhibition test with Raphidocelis subcapitata an EC10, EC20, EC50 and a LOEC values based on growth rate and yield were determined to be >100 mg/L. The 72-h NOEC was determined to be 100 mg/L. The results are based on nominal test item concentrations.

 

Toxicity to microorganisms:

Under the conditions of the performed Activated Sludge Respiration Inhibition Test, the EC10 and EC50 values of test item was determined as higher than 1000 mg/L. Based on the statistical evaluation in this test the NOEC was ≥ 1000 mg/L.

Additional information

Short-term toxicity to fish

A 96-h acute toxicity test with Brachydanio rerio was performed according to OECD guideline 203. The test item is a poorly water soluble material and therefore a saturated solution (100 mg/L nominal loading) was prepared and the fish were exposed unter static conditions to the test media containing the test item plus a control group for 96 hours. In this 96-hour static acute toxicity test on Zebrafish (Brachydanio rerio) the test item had no toxic effect on fish at aquatic saturation (equivalent to 100 mg/L nominal concentration). Accordingly, the 96-h LC50 value was determined to be > 100 mg/L. The 96-h NOEC was determined to be 100 mg/L. All validity criteria were met. The results are based on nominal test item concentration.

 

Short-term toxicity to Daphnia

A 48-h acute toxicity test with Daphnia magna was performed according to OECD guideline 202. The test item is a poorly water soluble material and therefore a saturated solution (100 mg/L nominal loading) was prepared and the daphnids were exposed unter static conditions to the test media containing the test item plus a control group for 48 hours. In this 48-hour static acute toxicity test on Daphnia magna the test item had no toxic effect on Daphnia magna at aquatic saturation (equivalent to 100 mg/L nominal concentration). Accordingly, the 48-h EC50 value was determined to be > 100 mg/L. The 48-h NOEC was determined to be 100 mg/L.

 

Toxicity to algae

A 72-h algal growth inhibition test with Raphidocelis subcapitata according to OECD guideline 201 was perfromed. The test item is a poorly water soluble material and therfore a saturated solution (100 mg/L nominal loading) was prepared and the alga (initial cell denisty: 10^4 cells/mL) were exposed to the test media containing the test item plus a control group for 72 hours. In this 72-h algal growth inhibition test with Raphidocelis subcapitata, the obtained results showed that the test item had no toxic effect on the algae at aquatic saturation (equivalent to 100 mg/L nominal concentration). Accordingly, the 72-h EC10, EC20, EC50 and the LOEC values based on growth rate and yield were determined to be >100 mg/L. The 72-h NOEC was determined to be 100 mg/L. The results are based on nominal test item concentrations.

 

Toxicity to microorganisms:

The purpose of the 3-hour test was to evaluate the influence of the test item on the activity of the activated sludge by measuring the respiration rate under defined conditions. The respiration rates (total, heterotrophic and nitrification oxygen uptake rates) of samples of activated sludge fed with synthetic sewage were measured in an enclosed cell containing an oxygen electrode after a contact time of 3 hours. Based on the preliminary information about the test item caused effect on the activated sludge inoculum, the test item was investigated at the concentration of 1000 mg/L as a limit concentration, only. Under the conditions of the performed Activated Sludge Respiration Inhibition Test, the EC10 and EC50 values of test item was determined as higher than 1000 mg/L. Based on the statistical evaluation in this test the NOEC was ≥ 1000 mg/L.