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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Monograph used by the fragrance industry.

Data source

Reference
Reference Type:
review article or handbook
Title:
Monographs on Fragrance Raw Materials
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
p.704

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
RIFM protocol in 1973
GLP compliance:
no

Test material

1
Reference substance name:
Thyme, Thymus zygis, ext.
EC Number:
285-397-0
EC Name:
Thyme, Thymus zygis, ext.
Cas Number:
85085-75-2
Molecular formula:
not relevant for a UVCB substance
IUPAC Name:
Thyme, Thymus zygis, ext.
Test material form:
liquid: volatile
Details on test material:
UVCB

Test animals

Species:
rat

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
> 3 750 - < 5 670 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute oral LD50 value in rats was reported 4.70 g/kg (Moreno, 1973).