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Physical & Chemical properties

Water solubility

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Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Adopted May 2008
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Remarks:
In a preliminary test, the water solubility of the test item was found to be > 10E-2 g/L (approximately 600 g/L). Therefore the flask method was chosen for the determination of the water solubility.
Water solubility:
521.814 g/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
10.1
Remarks on result:
other: demineralized water
Water solubility:
533.16 g/L
Conc. based on:
test mat.
Incubation duration:
48 h
Temp.:
20 °C
pH:
10.2
Remarks on result:
other: demineralized water
Water solubility:
526.518 g/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
10.3
Remarks on result:
other: demineralized water
Key result
Water solubility:
527 g/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: Mean value
Details on results:
Due to the high water solubility at 30 °C a very high concentration would have been necessary to obtain a turbid solution. This high concentration became very viscous at 20 °C which affected stirring of the solutions so much that satisfying stirring could not be guaranteed.
Therefore the test concentration was reduced and the solutions were stirred at 20 °C.
The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met.

In a preliminary test, a solubility of approx. 600 g/L was estimated.

In a first step the concentration of the main test was applied as two to three times the estimated water solubility. This concentration was completely soluble at 30 °C. Due to the high water solubility at 30 °C a very high concentration was necessary to obtain a turbid solution. This high concentration became very viscous at 20 °C which affected stirring of the solutions so much that satisfying stirring could not be guaranteed.

Therefore the test concentration was reduced to approx. 1000 g/L and the solutions were stirred at 20 °C. At this temperature and concentration lightly turbid solutions were obtained. In Currenta Study 2014/0075/11 it was demonstrated that the test item is stable for 5 days at 50 °C. The solutions stayed turbid until the end of the test.

Conclusions:
The water solubility of the test item EGGE 2806-1 at 20 °C is 527 g/L.
Executive summary:

The water solubility of the test item EGGE 2806-1 in demineralized water was determined with the flask method at 20 °C according to OECD TG 105. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection. Water solubility of EGGE 2806-1 at 20 °C is 527 g/L.

Description of key information

The water solubility of the test item EGGE 2806-1 in demineralized water was determined with the flask method at 20 °C according to OECD TG 105. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection. Water solubility of EGGE 2806-1 at 20 °C is 527 g/L.

Key value for chemical safety assessment

Water solubility:
527 g/L
at the temperature of:
20 °C

Additional information