Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-045-1 | CAS number: 24157-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Description of key information
A reproductive/developmental toxicity screening test is waived as a pre-natal developmental toxicity study conducted with an analogue source substance is available.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A reproductive/developmental toxicity screening test for 2,6-diisopropylnaphthalene (CAS No. 24157-81-1) is not necessary according to the specific adaptation option laid down in Regulation (EC) No. 1907/2006 (REACH), Annex VIII, Section 8.7.1, Column 2 as a pre-natal developmental toxicity study conducted with an adequate analogue source substance is available.
Effects on developmental toxicity
Description of key information
Pre-natal developmental toxicity (OECD 414): NOAEL (maternal) = 100 mg/kg bw/day, NOEL (embryo-/fetotoxicity, teratogenicity) = 625 mg/kg bw/day (highest dose tested)
Read-across from analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9)
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day (nominal)
- Basis for effect level:
- other: maternal toxicity
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Leuschner, 1993
- Dose descriptor:
- LOAEL
- Effect level:
- 250 mg/kg bw/day (nominal)
- Basis for effect level:
- other: maternal toxicity
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Leuschner, 1993
- Key result
- Dose descriptor:
- NOEL
- Remarks:
- highest dose tested
- Effect level:
- 625 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Basis for effect level:
- other: no effects observed
- Remarks on result:
- other: Source: CAS No. 38640-62-9, Leuschner, 1993
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Conclusions:
- The treatment of pregnant rats produced no pathologically relevant effects, neither in the dams nor in the offspring. Transient significant reduction in feed consumption and body weight gain were observed during maternal development. With respect to the maternal body weight effect, the NOAEL for maternal toxicity is established to be 100 mg/kg bw/day. Due to the absence of embryotoxic effects, the highest dose tested, 625 mg/kg bw/day, corresponds to a NOEL for embryo-/fetotoxic effects and teratogenicity.
- Executive summary:
The developmental toxicity of the target substance is predicted based on an adequate and reliable prenatal developmental toxicity study of a structural analogue source substance. Treatment of pregnant rats with the test substance at 250 and 625 mg/kg bw/day induced a maternal toxic response which was reflected in a reduction in feed consumption and body weight gain. At 100 mg/kg bw/day, the test substance did not cause maternal toxicity. Doses up to 625 mg/kg bw/day did not induce fetotoxicity and did not show teratogenic potential. As explained in the analogue justification, the differences in molecular structure between the target and the source substances are unlikely to lead to differences in the carcinogenic potential.
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No data on developmental toxicity with 2,6-diisopropylnaphthalene (CAS 24157-81-1) are available. The endpoint, therefore, is assessed by means of read-across from the analogue source substance bis(isopropyl)naphthalene (CAS 38640-62-9).
The pre-natal developmental toxicity of bis(isopropyl)naphthalene (CAS No. 38640-62-9) was investigated in a study according to OECD guideline 414 and in agreement with GLP provision (Leuschner, 1993). Groups of 20 pregnant Sprague-Dawley rats were treated by gavage with the test substance in sesame oil at dose levels of 100, 250, and 625 mg/kg bw/day from Day 6 to Day 15 of gestation. A further group of pregnant females was exposed to the vehicle sesame oil only (control). Doses were selected based on a preliminary dose range-finding study. Clinical signs, body weight development, food and water consumption were monitored during the duration of the study. At sacrifice (at Day 20 of gestation) all females were subjected to gross necropsy including examination of the uterine contents. The number of corpora lutea, number, position and type of implantation, placental weight, foetal weight, sex and external and internal macroscopic appearance were recorded. Half of each litter were examined for detailed skeletal development and the remaining half were subjected to detailed visceral examination. No substance-related mortality and no clinical signs were observed in the treated dams. Body weight gain was dose-related inhibited in the dams treated with 250 and 625 mg/kg bw/day. At the end of the study, the net body weight change was lower than in the controls. Food consumption showed a significant reduction at 250 and 625 mg/kg bw/day. Treatment did not influence drinking water consumption. No substance-related pathological changes were detected at autopsy. Regarding fetal development, no distinct influence on prenatal development was detected. External macroscopic inspection and examination of soft tissue revealed no substancerelated variations and/or retardations. Based on these findings and accounting for the maternal body-weight effect, the no-observed-adverse-effect-level (NOAEL) for maternal toxicity was established at 100 mg/kg bw/day. Due to the absence of developmental effects, the highest dose (625 mg/kg bw/day) corresponds to the no-observed-effect-level (NOEL) for embryo-/fetotoxicity and teratogenicity.
Justification for classification or non-classification
According to Regulation (EC) No. 1907/2006 (REACH), Annex VIII, Section 8.7.1, Column 2, a screening test for reproductive/developmental toxicity is not required as a pre-natal developmental toxicity study is available. Under these circumstances, the available data on reproductive and developmental toxicity are considered as sufficient to allow a conclusive evaluation in regard to ‘reproductive toxicity’ as defined in Title 1, Chapter 1 of Regulation (EC) No. 1272/2008 (CLP). The available data on developmental toxicity for the analogue source substance bis(isopropyl)naphthalene (CAS No. 38640-62-9) do not meet the criteria for classification according to the CLP Regulation. Data are, therefore, conclusive but not sufficient for classification. Based on an analogue read-across approach, the target substance 2,6-diisopropylnaphthalene (CAS No. 24157-81-1) is also not expected to exhibit developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.