Registration Dossier
Registration Dossier
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EC number: 233-310-1 | CAS number: 10114-46-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-hydroxy-1-methyl-3-[(3-nitrophenyl)azo]-2-quinolone
- EC Number:
- 229-219-1
- EC Name:
- 4-hydroxy-1-methyl-3-[(3-nitrophenyl)azo]-2-quinolone
- Cas Number:
- 6439-53-8
- Molecular formula:
- C16H12N4O4
- IUPAC Name:
- 4-hydroxy-1-methyl-3-[(3-nitrophenyl)diazenyl]quinolin-2(1H)-one
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2% and 30%
- Justification for choice of vehicle: dispersant - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 6 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured
- Clinical signs:
- diarrhea, urine and faeces yellowish coloured
- Gross pathology:
- heart dilatation, stomach dilatation, grayish-brown colorit in nephrons
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 (oral, gavage) is ca. 6500 mg/kg bw. Therefore the GHS criteria are not met, the substance is not classifiable.
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