Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 309-011-8 | CAS number: 99688-45-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977/78
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
- Test type:
- other: BASF method
- Limit test:
- yes
Test material
- Reference substance name:
- Trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphth[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone
- EC Number:
- 309-011-8
- EC Name:
- Trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphth[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone
- Cas Number:
- 99688-45-6
- Molecular formula:
- C45H17Cl3N2O5
- IUPAC Name:
- 1,2,3-trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphtho[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone
- Test material form:
- solid
- Details on test material:
- Vat Green 13
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5% aqueous solution
- Details on oral exposure:
- Concentration in vehicle: 1.5 to 35%
- Doses:
- 10000 mg/kg bw
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0, 14 d
- Necropsy of survivors performed: yes - Statistics:
- NA
Results and discussion
- Preliminary study:
- NA
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- None
- Clinical signs:
- None
- Body weight:
- No effect
- Gross pathology:
- No findings
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study, the LD50 of the test item was determined to be >10000 mg/kg bw in rats.
- Executive summary:
In an acute oral toxicity study, rats were given a single oral dose of 1.5 - 35 % suspension of the test item diluted in 0.5% aqueous carboxymethylcellulose and were observed for 7 days. Adverse clinical signs of toxicity were not obsevred. Moreover, gross pathological findings were anot found. Based on the results from this study, the LD50 of the test item was determined to be >10000 mg/kg in rats (test. mat.).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
