Registration Dossier

Administrative data

Description of key information

[2-(Perfluorohexyl)ethyl]triethoxysilane has been tested in an acute oral toxicity study conducted according to OECD 423 and in compliance with GLP. The LD50 was determined to be >2000 mg/kg bw (Hüls, 1997a).

The key study for acute dermal toxicity reported an LD₅₀ value of > 2000 mg/kg bw [2-(perfluorohexyl)ethyl]triethoxysilane, determined in a reliable study conducted according to GLP and current OECD TG 403 (Hüls, 1997b).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

[2-(Perfluorohexyl)ethyl]triethoxysilane has been tested in an acute oral toxicity study conducted according to OECD 423 and in compliance with GLP (Hüls, 1997a). The undiluted test substance was administered by gavage to a group of 3 male and 3 female rats. The rats were dosed at 2000 mg/kg bw. There were no deaths and no signs of systemic reaction to treatment. All animals achieved satisfactory bodyweight gains throughout the study. The LD50 was determined to be >2000 mg/kg bw.

[2-(Perfluorohexyl)ethyl]triethoxysilane has been tested for acute dermal toxicity to rats in a study conducted according to OECD TG 402 and in compliance with GLP (Hüls, 1997b). No mortalities or clinical signs were observed in any of the five male and five female animals exposed for 24 hours to 2000 mg/kg bw of undiluted test substance, either during exposure or in the following 14 day observation period. It is concluded that the LD₅₀ is ˃2000 mg/kg bw.

Justification for classification or non-classification

Based on the available studies on acute toxicity, [2-(perfluorohexyl)ethyl]triethoxysilane does not require classification for acute toxicity according to Regulation (EC) 1272/2008.