N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamide

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-08-17

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Version / remarks:

1981

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

2009

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Version / remarks:

2009

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

2017-02-28

Type of method:

Laser scattering/diffraction

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamide

EC Number:

233-360-4

EC Name:

N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamide

Cas Number:

10128-55-9

Molecular formula:

C24H16N2O4S

IUPAC Name:

N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamide

Test material form:

solid: particulate/powder

Details on test material:

- Appearance: Off white powder

Specific details on test material used for the study:

- Storage conditions: Ambient temperature, dry, tightly closed in original container

Results and discussion

Remarks on result:

not measured/tested

Particle size

Particle size 1

Percentile:

D10

Mean:

3.8 µm

St. dev.:

0

Particle size 2

Percentile:

D50

Mean:

14.3 µm

St. dev.:

0

Particle size 3

Percentile:

D90

Mean:

43.25 µm

St. dev.:

0.92

Particle size distribution at different passages

Remarks on result:

not measured/tested

Any other information on results incl. tables

Two test series of 3 measurements each were performed with the test item.

Test series 1:

D₁₀:      3.8 µm

D₅₀:      14.3 µm         (Median diameter)

D₉₀:      43.9 µm

Test series 2:

D₁₀:      3.8 µm

D₅₀:      14.3 µm         (Median diameter)

D₉₀:      42.6 µm

Average

D₁₀:      3.8 µm

D₅₀:      14.3 µm         (Median diameter)

D₉₀:      43.2 µm

Final Results

The test itemN-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamidehas a median particle size D₅₀ = 14 µm, which was determined by laser diffraction measurement in accordance to inter alia ISO 13320 (2009) andCIPAC MT 187 (2009) method.

Applicant's summary and conclusion

Conclusions:

The test item N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]naphthalene-2-sulphonamide has following particle size distribution, which was determined by laser diffraction measurement in accordance to inter alia ISO 13320 (2009) and CIPAC MT 187 (2009) method:
D10: 3.8 µm
D50: 14.3 µm (Median diameter)
D90: 43.2 µm