Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose:
read-across: supporting information

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1999

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Tests in inhalation chambers
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
hexane (isomer composition and purity were not specified)

Test animals / tissue source

Species:
human

Test system

Vehicle:
other: air (tested in inhalation chambers)
Duration of treatment / exposure:
3-5 min
Number of animals or in vitro replicates:
10 volunteers

Results and discussion

In vivo

Results
Irritation parameter:
other:
Basis:
mean
Time point:
other: after 3-5 min. in inhalation chamber
Score:
ca. 0
Remarks on result:
no indication of irritation

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Hexane is not irritant to the eye, when humans are exposed up to 500ppm in the air for a few minutes.
Direct contact with n-hexane vapor (3000 ppm for 24 wk with 5 d/wk for 8 hr/d) with the eyes of rabbits resulted in lacrimation and hyperemia of the conjunctivae.