Registration Dossier

Administrative data

Endpoint:
specific investigations: other studies
Remarks:
pulmonary absoption
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose:
read-across: supporting information

Data source

Reference
Reference Type:
review article or handbook
Title:
2-METHYLPENTANE (ISOHEXANE)
Author:
Galvin, Jennifer B.; Bond, Gary
Year:
1999
Bibliographic source:
Journal of Toxicology and Environmental Health, Part A, 58:1-2, pp. 81-92, DOI: 10.1080/009841099157449; http://dx.doi.org/10.1080/009841099157449

Materials and methods

Endpoint addressed:
other: pulmonary absorption

Test material

Reference
Name:
Unnamed
Test material form:
liquid

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
80-100 min.
Details on study design:
1000–5000 ppm
Studies on pulmonary absorption of 20 inhaled gasoline-related hydrocarbon vapors — % of inhaled hydrocarbon retained; 80–100 min

Results and discussion

Details on results:
24.7% Uptake for 2-methyl-pentane

Applicant's summary and conclusion

Conclusions:
24.7% uptake of 2-methyl-pentane by pulmonary absoption
Executive summary:

This is a brief summary of: American Petroleum Institute. 1987. API Med. Res. Pub. 34-33036, October.