Phosphoric acid, C12-18-alkyl esters, potassium salts

Endpoint summary

Description of key information

Short-term toxicity to fish:

96-h-LC50: > 100 mg/L (nominal, WAF)

 

Short-term toxicity to aquatic invertebrates:

48h-EC50: > 100 mg/L (nominal, WAF) 

 

Toxicity to aquatic algae and cyanobacteria: 

72h-EC50 of > 100 mg/L (grow, nominal, WAF)

72h-NOEC of ≥100 mg/L (grow, nominal, WAF)

Toxicity to microorganisms: 

3h-NOEC: > 1000 mg/L

Additional information

Short-term toxicity to fish:

Available data from 1-Octadecanol, phosphate, potassium salt were used to evaluate the acute toxicity on fish for Phosphoric acid, C12-18-alkyl esters, potassium salts.

In a 96-h acute toxicity study, Danio rerio were exposed to the read-across substance 1-Octadecanol, phosphate, potassium salt at concentrations of 0 and 100.0 mg/L nominal (WAF of 100 mg/L) under static conditions.

The 96h-LC50 was determined to be > 100 mg/L  (WAF based on nominal concentration).

The 96h-NOEC was determined to be ≥ 100 mg/L  (WAF based on nominal concentration). 

These values were used for chemical safety assessment of Phosphoric acid, C12-18 alkyl esters, potassium salts.

 

Short-term toxicity to aquatic invertebrates:

The 48-hr-acute toxicity of Phosphoric acid, C12-18 alkyl esters, potassium salts to Daphnia magna was studied under static conditions according to OECD Guideline 202.

Daphnids were exposed to control and test chemical at nominal concentrations of 1.0, 2.0, 4.0, 7.0, 10, 22, 48, 100, 200 mg/L a.i./L in fresh water for 48 h.

The 48-hour EC50 was > 200 mg/L nominal (based on mobility).

 

Similar results were obtained with the read-across substance 1-Octadecanol, phosphate, potassium salt. In a study concocted according to OECD guideline 202, the 48h-EC50 was determined to be > 100 mg/L (WAF based on nominal concentration). The NOEC was determined to be ≥ 100 mg/L (WAF based on nominal concentration).

The 48-hour EC50 of 100 mg/L was used for chemical safety assessment of Phosphoric acid, C12-18 alkyl esters, potassium salts.

 

Toxicity to aquatic algae and cyanobacteria: 

Available data from 1-Octadecanol, phosphate, potassium salt were used to evaluate toxicity to algae for Phosphoric acid, C12-18-alkyl esters, potassium salts.

The toxicity of the read-across substance 1-Octadecanol, phosphate, potassium salt on the growth of the fresh water green alga Desmodesmus subspicatus was tested in a study according to OECD guideline 201.

No significant effects were observed up to and including the highest test concentration (WAF of 100 mg/L 1-Octadecanol, phosphate, potassium salt).

Growth rate:

72h-EC50: > 100 mg/L (nominal, WAF)

72h-NOEC:≥100 mg/L (nominal, WAF)

 

Yield:

72h-EC50: > 100 mg/L (nominal, WAF)

72h-NOEC:≥100 mg/L (nominal, WAF)

A 72h-NOEC of 100 mg/L was used for chemical safety assessment of Phosphoric acid, C12-18 alkyl esters, potassium salts.

 

Toxicity to microorganisms: 

Available data from 1-Octadecanol, phosphate, potassium salt were used to evaluate toxicity to microorganisms for Phosphoric acid, C12-18-alkyl esters, potassium salts.

The toxicity to microorganisms of the read-across substance 1-Octadecanol, phosphate, potassium salt was tested in a study according to OECD guideline 209 using activated sludge from a domestic sewage treatment plant as inocumlum.

No significant inhibition was observed at the highest test concentration of 1000 mg/L 1-Octadecanol, phosphate, potassium salt.

3h NOEC ≥ 1000 mg/L

3h EC20 > 1000 mg/L

3h EC50 > 1000 mg/L

A 3h-NOEC of 1000 mg/L was used for chemical safety assessment of Phosphoric acid, C12-18 alkyl esters, potassium salts.

Justification for read-across

Evaluation of structure-activity relationship is based on data from structural similar substances with the same basic structure, potassium salts of phosphoric acid alkyl ester, varying mainly in the chain length of fatty acid moiety. A detailed justification document for the read-across is attached in the respective target records of IUCID.