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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18.-19.07.2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
no
Type of method:
effusion method: vapour pressure balance
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0 Pa
Temp.:
50 °C
Vapour pressure:
0 Pa

The vapour pressure was measured in the temperature range of 75 °C to 100 °C. After the measurement a mass loss of approx. 1 % (w/w) was determined.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C

Vapour pressure / hPa

75

1.5 x 10-5

80

n.e.

85

9.1 x 10-6

90

2.0 x 10-5

95

3.3 x 10-5

100

7.0 x 10-5

n.e.: not evaluable

 

The data point measured at 75 °C was not included in the linear regression because it shows a typical deviation caused by volatile impurities at the beginning of a measurement.

The data point measured at 85 °C was not included in the linear regression because it was below the detection limit of the method.

The values for 20, 25 and 50 °C are calculated, using the Antoine constants A, B and C as shown in Table 2.

Table 2: Antoine parameters and extrapolated vapour pressures

T/°C

p/ hPa

log (p/hPa) = A + B/(C+T[°C])

20

2.8 x 10-10

A= 15.49592

25

7.3 x 10-10

B = -7344.62

50

5.9 x 10-8

C= 273.15

Conclusions:
The vapour pressure of the test substance was 2.8e-8 Pa at 20 °C, 7.3e-8 Pa at 25 °C and 5.9e-6 Pa at 50 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 75 and 100 °C. After the last measurement a mass loss of approx. 1 % (w/w) was determined. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 2.8 x 10-8 Pa at 20 °C, 7.3 x 10-8 Pa at 25 °C and 5.9 x 10-6 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test substance was 2.8e-8 Pa at 20 °C, 7.3e-8 Pa at 25 °C and 5.9e-6 Pa at 50 °C, respectively (reference 4.6-1).

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 75 and 100 °C. After the last measurement a mass loss of approx. 1 % (w/w) was determined. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 2.8 x 10-10 Pa at 20 °C, 7.3 x 10-10 Pa at 25 °C and 5.9 x 10-8 Pa at 50 °C, respectively (reference 4.6-1).