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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: 16 CFR 1500.41
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OPP 81-5 (Acute Dermal Irritation)
Deviations:
not specified
GLP compliance:
no
Remarks:
study was conducted prior to the GLP legislation

Test material

Constituent 1
Chemical structure
Reference substance name:
3-mercaptopropane-1,2-diol
EC Number:
202-495-0
EC Name:
3-mercaptopropane-1,2-diol
Cas Number:
96-27-5
Molecular formula:
C3H8O2S
IUPAC Name:
3-sulfanylpropane-1,2-diol
Test material form:
liquid: viscous
Specific details on test material used for the study:
Batch 297-1382

Test animals

Species:
rabbit
Strain:
other: Albino, not further specified

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
6
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not reported

OBSERVATION TIME POINTS
24 + 72 h

SCORING SYSTEM:
Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
3
Max. score:
4
Reversibility:
not fully reversible within: 72 h
Remarks on result:
positive indication of irritation
Remarks:
only 24 and 72 h readings wer conducted
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
3.42
Max. score:
4
Reversibility:
not fully reversible within: 72 h
Remarks on result:
positive indication of irritation
Remarks:
only 24 and 72 h readings wer conducted
Irritant / corrosive response data:
Rabbit # Time [h]
erythema oedema
1 24 2 3
72 4 3
average 3.0 3.0
2 24 2 4
72 4 4
average 3.0 4.0
3 24 2 4
72 4 3
average 3.0 3.5
4 24 2 4
72 4 4
average 3.0 4.0
5 24 2 3
72 4 3
average 3.0 3.0
6 24 2 3
72 4 3
average 3.0 3.0

Time [h]
erythema oedema
average 24 2.00 3.50
72 4.00 3.33
24/72 3.00 3.42

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Based the average erythema and oedema scores of 3.0 and 3.4, respectively, TG should be classified as skin irritant (Skin Irrit 2).