1-[2,3-dihydro-1,1,2,6-tetramethyl-3-(1-methylethyl)-1H-inden-5-yl]ethan-1-one

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1977

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

male/female

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2.01; 2.41; 2.89; 3.47 or 4.17mL / kg bw

No. of animals per sex per dose:

3

Control animals:

yes

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2.22 mL/kg bw

Based on:

test mat.

95% CL:

2.03 - 2.44

Mortality:

Death ocurred between 3h and 7 days after dosing.

Clinical signs:

Rats shiwed sluggishness and humpback behaviour. Some of the rats lost consiousness. Within 24 hours after treatment green.coloured urine was observed in all dose groups.
After 24 hours all rats showed urine stains on the fur of the abdominal region. They produced red coloured urine.

Body weight:

Males: 122 - 236 g
Females: 95-195 g

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The material can be classified as slightly toxic.

Reference 2

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1978

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

Yound adults albino rats (wistar derived) from the INstitute's colony were used. The body weight of males varied from 170 to 262g and those for females from 95 to 170g. The rats were housed in groups of three, in screened-bottomed, stainless steel, cages in a well-ventilated room maintained at 23-25°C

Route of administration:

oral: gavage

Vehicle:

propylene glycol

Doses:

4; 6; 9; 13.4 and 20.3 mL

No. of animals per sex per dose:

3

Control animals:

not specified

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1.68 mg/kg bw

Based on:

test mat.

95% CL:

1.34 - 2.11

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The material can be classified as slightly toxic.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Justification for classification or non-classification

The material can be classified as slightly toxic.