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EC number: 201-739-3 | CAS number: 87-32-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 13.02. - 28.08.1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Nα-acetyl-DL-tryptophan
- EC Number:
- 201-739-3
- EC Name:
- Nα-acetyl-DL-tryptophan
- Cas Number:
- 87-32-1
- Molecular formula:
- C13H14N2O3
- IUPAC Name:
- N-acetyltryptophan
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Russian Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Asta Werke, Bielefeld
- Age at study initiation: about 5 - 6 month
- Weight at study initiation: 2,1 - 2,3 kg
- Housing: single
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1 °C
- Humidity (%): 50 - 60 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 / 12 h
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 g
- Observation period (in vivo):
- 1, 24, 48 and 72 hours after administration
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: DRAIZE
TOOL USED TO ASSESS SCORE: hand-slit lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of animal #1 and #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of animal #1 and #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- Slight conjunctivae (score 1) was observed in 1/3 rabbits at the 1-h reading time point, which persisted until 24 h after installation. The conjunctivae had cleared completely within 48 h. Swelling (score 2) was observed in 1/rabbits at the 1-h reading time point, but cleared completely within 24 h. The iris in 1/3 rabbits showed congestion, swelling and moderate circumcorneal hyperaemia of score 1 at the 24-h reading time point. This effect was totally reversible within 48 h. In 2/3 rabbits the corneas showed scattered or diffuse areas of opacity of score 1 at the 1-h reading time point which was fully reversible within 24 h and 48 h, respevtively. In 1/3 rabbits a score of 2 was obtained for the cornea at the 1-h reading time point, which persisted until 24 h after installation. In this animal, a score of 1 was observed at the 48-h and 72-h reading time point.
Any other information on results incl. tables
Table 1: Results of the in vivo eye irritation study
Rabbit # | Time [h] | conjunctivae | iris | cornea | |
redness | swelling | ||||
1 | 1 | 0 | 0 | 0 | 1 |
24 | 0 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | 0 | |
average | 0,0 | 0,0 | 0,0 | 0,0 | |
2 | 1 | 0 | 0 | 0 | 1 |
24 | 0 | 0 | 0 | 1 | |
48 | 0 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | 0 | |
average | 0,0 | 0,0 | 0,0 | 0,3 | |
3 | 1 | 1 | 2 | 0 | 2 |
24 | 1 | 0 | 1 | 2 | |
48 | 0 | 0 | 0 | 1 | |
72 | 0 | 0 | 0 | 1 | |
average | 0,3 | 0,0 | 0,3 | 1,3 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation(EC) No. 1272/2008
- Conclusions:
- CLP: not classified
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