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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 Jul - 28 Aug 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to other study
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Version / remarks:
adopted in 1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
adopted in 2008
Deviations:
no
GLP compliance:
no
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
Storage conditions: ambient temperature (10 – 30 °C)
Decomposition:
yes
Decomp. temp.:
208.6 °C
Remarks on result:
other: Test item melted under decomposition.

Results
DSC
Two DSC measurements showed an endothermal effect after the melting in the temperature range of 230 – 325 °C. However, as the melting was already accompanied by decomposition, it can be assumed that further decomposition occurred and the observed endothermal effect could have been either a gas development caused by the decomposition and/or partial boiling of the test item/decomposition products. No further endothermic nor exothermic effects were seen up to the final test temperature of 500 °C. The mass loss after DSC measurement was 67%.

Table 1 – Boiling point – DSC measurement

Test item [mg]

Final temperature [°C]

Temperature range (boiling) [°C]

Onset [°C]

Observations

7.76

500

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Mass loss 67%

7.78

Mass loss 68%

 

The test item N-Acetyl-LD-Tryptophan had no boiling point as it melted under decomposition.

Description of key information

Substance had no boiling point under atmospheric conditions (OECD 103, DSC).

Key value for chemical safety assessment

Additional information

Substance melted under decomposition starting at 208.6 °C.