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EC number: 479-310-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and appropriate guidelines
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- n/a
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- E-AF098T (Lot No. T 157), a white powder. Stored at room temp. (Approximately 25oC).
The test material was stable for the duration of the study.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: Charles River Laboratories, Inc.
Male and nulliparous, nongravid female. Age: Approximately 7 weeks old. Bodyweight: 187-208 gr males, 155-176 gr femaels). Daily average animal
room temperature and relative humidity: 69 ± 2oF and 67± 5%, respectively.
Identification by Earmark.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Corn oil (50% formulation)
- Details on oral exposure:
- Oral gavage, using a syringe equipped with a stainless steel ball-tipped intubation needle. Dosing volume of 10 ml/kg body weight.
Fasting Food was withheld overnight prior to dosing until approx. 4 hours after administration of the test substance.
Frequency: Single dose on day 1. 14 days observation. - Doses:
- 5 gr/kg (5000 mg/kg) of fasted body weight using a dosing volume of 10 ml/kg body weight.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- All animals were dosed 5000mg/kg bodyweight, once only, by gavage. The animals were observed for mortality/moribundity or over sight of toxicity for 14 days. At the end of the study, the animals were killed and subjected to gross pathological examination.
Frequesncy of observation:
Mortality/Viability- Twice daily
Body weights- Days 1 (pre administration), 8 and 15.
Clinical signs- At periodic intervals on day of dosing (day 1) and once daily thereafter.until day 15.
Necropsy- At the end of the observation period, all animals were sacrificed by asphyxiation using oxygen/carbon dioxide procedure and subjected
to necropsy. Descriptions of all internal macroscopic abnormalities were recorded. - Statistics:
- Statistical analysis was limited to calculation of means and standard deviations of body weight and body weight change.
Results and discussion
- Preliminary study:
- n/a
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- None of the rats died during the study
- Clinical signs:
- No clinical signs of toxcity were observed in any of the animals for the duration of the study.
- Body weight:
- All rats gained weight during the study.
- Gross pathology:
- No gross necropsy findings were observed
- Other findings:
- no further information
Any other information on results incl. tables
no further information
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 5000 mg/kg bw
- Executive summary:
The Acute oral toxicity test of Fyrolflex SOL-DP (E-AF098T) was conducted in male and female rats. There were no deaths during the study. No signs of systemic toxicity were noted. No macroscopic abnormalities were detected. The acute oral median lethal dose (LD50) of the test material in the Sparague- Dawley CD strain rat was found to be greater than 5000 mg/kg body weight.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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