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EC number: 225-806-1 | CAS number: 5089-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-09-07 to 1994-10-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): activated sludge from a primarily communal sewage treatment plant (Marl- East)
- Preparation of inoculum for exposure: washed
- Concentration of sludge: 27.6 g/ml - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10.7 other: mg/L DOC
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 21.9-22.2°C
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 2L Erlenmeyer flasks with loose closure of aluminium foil
- Number of culture flasks/concentration: two test substance flasks, two control flasks, two innoculum blank flasks.
SAMPLING
- Sampling frequency: 0 hours, 3 hours, 7, 14, 21, 27, 28 days
- Sampling method: samples were centrifuged at 3000RPM for 15 min, then duplicate determination of oxygen-enriched and de-gassed samples
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 10.8 mg/L DOC
- Parameter:
- % degradation (DOC removal)
- Value:
- 39
- Sampling time:
- 28 d
- Details on results:
- Biodegradation of reference substance was 98% after 7 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- A biodegradation result of 39% in 28 days (DOC) was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification for grouping of substances in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (DOC removal)
- Value:
- 39
- Sampling time:
- 28 d
Referenceopen allclose all
Table 1: Dissolved organic carbon levels (mg/l) and calculated % DOC reduction
Type of suspension |
0 |
3 hours |
7 |
14 |
21 |
27 |
28 |
|||||||
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction % |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
DOC (mg/l) |
DOC reduction (%) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Test sample - median value flask 1 |
8.49 |
0 |
8.27 |
0 |
4.77 |
47.59 |
4.76 |
45.81 |
4.48 |
48.98 |
4.71 |
48.10 |
5.21 |
41.75 |
Test sample - median value flask 2 |
8.88 |
0 |
8.37 |
0 |
4.97 |
45.74 |
4.54 |
49.25 |
4.49 |
49.50 |
4.47 |
51.75 |
5.74 |
35.84 |
Test sample - Mean value |
|
0 |
|
0 |
|
47 |
|
48 |
|
49 |
|
50 |
|
39 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Blank mean value |
0.51 |
- |
0.39 |
|
0.64 |
- |
0.49 |
- |
0.46 |
- |
0.62 |
- |
0.62 |
- |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Reference substance – median value flask 1 |
11.64 |
0 |
11.89 |
0 |
0.82 |
98.43 |
0.64 |
98.70 |
0.51 |
99.57 |
0.72 |
99.13 |
0.74 |
98.96 |
Reference substance – median value flask 2 |
11.31 |
0 |
11.44 |
0 |
0.83 |
98.28 |
0.51 |
99.82 |
0.52 |
99.46 |
0.76 |
98.73 |
0.82 |
98.19 |
Median value |
|
0 |
|
0 |
|
98 |
|
100 |
|
100 |
|
99 |
|
99 |
Description of key information
Not readily biodegradable (39% in 28 days, EU Method C.4-A) based on read across data from CAS 1760 -24 -3.
Key value for chemical safety assessment
Additional information
There are no reliable ready biodegradation data available for N-[3-(triethoxysilyl)propyl]ethylenediamine (CAS 5089-72-5), therefore good quality data for the analogue, N-(3-(trimethoxysilyl)propyl)ethylenediamine (CAS 1760-24-3), have been read across. Both substances share the same silanol hydrolysis product, N-[3-(trihydroxysilyl)propyl]ethylenediamine, the other hydrolysis products are ethanol and methanol, which were readily biodegradable. Both substances are expected to hydrolyse within the timescale of a ready biodegradation test.
Both N-[3-(triethoxysilyl)propyl]ethylenediamine (CAS 5089-72-5) and N-(3-(trimethoxysilyl)propyl)ethylenediamine (CAS 1760-24-3) are within a wider analogue group. Substances within this wider analogue group, in general, exhibit no evidence of any significant biodegradation once hydrolysis and subsequent biodegradation of alkoxy/acetoxy groups has been taken into account. It is therefore considered valid to read-across the results for N-(3-(trimethoxysilyl)propyl)ethylenediamine to fill the data gap for the registered substance. The other hydrolysis products for the two substances are ethanol and methanol, which are readily biodegradable (OECD, 2004a and OECD, 2004b).
This wider analogue group for the ready biodegradability endpoint consists of a number of sub-classes of substances. However, read-across is carried out between substances with the same sub-class in most cases.
Table 4.1.4 presents ready biodegradation data available for substances within the sub-class (III-8) of chlorosilanes, siloxanes, silanes and alkoxysilanes etc, with amino functional group(s) in side chain after any very rapid hydrolysis has been accounted for. Both N-[3-(triethoxysilyl)propyl]ethylenediamine (CAS 5089-72-5) and N-(3-(trimethoxysilyl)propyl)ethylenediamine (CAS 1760-24-3) are members of this sub-class.
The key study (1994) was performed according to EU method C.4 (Determination of the “ready” biodegradability - Dissolved organic carbon (DOC) Die-away-test) and GLP. The biodegradation values calculated from Dissolved Oxygen Depletion performed during the test of 28 days revealed 11.1% at 2 mg/l test concentration. Therefore, the test item was not readily biodegradable under the conditions in the closed bottle test performed. N-(3-(trimethoxysilyl)propyl)ethylenediamine is not readily biodegradable, the observed biodegradation (39% after 28 days) is of the hydrolysis product methanol. The study is considered to be reliability 1 (reliable without restrictions).
Table 4.1.4: Ready biodegradation data available for substances within the relevant sub-class (III-8) of chemicals.
CAS |
Name |
Readily biodegradable? Yes/no |
Result: Biodegradation after 28 day |
Guideline |
Reliability |
Corrected % biodegradation once alkoxy/acetoxy biodegradation is accounted for |
027445-54-1 |
Cyclohexanamine,N-[(diethoxymethylsilyl)methyl]- |
No |
29% (26% taking into account nitrification) |
OECD 301F |
1a |
-7 (i.e 0) |
[N,N-Bis(trimethylsilyl)aminopropyl]methyldiethoxysilane |
No |
23% (BOD); 22% (TOC) |
OECD 301C |
1a |
-6 (i.e 0) |
|
000919-30-2 |
3-aminopropyltriethoxysilane |
No |
67% |
Annex V C4-A |
1a |
0 |
031024-56-3 |
N-[3-(trimethoxysilyl)propyl]butylamine |
No |
24.7% |
OECD 301B |
1a |
-5 (i.e 0) |
227085-51-0 |
N-ethyl-3-trimethoxysilyl-2-methylpropanamine |
No |
16 - 18% |
OECD 301F |
1a |
-15 (i.e 0) |
157923-74-5 |
2,2-dimethyl-4-(trimethoxysilyl)butylamine |
No |
36% |
OECD 301F |
1a |
3 |
003069-33-8 |
N-[3-(methoxydimethylsilyl)propyl]ethylenediamine |
No |
11.1% |
OECD 301D |
1a |
-1 (i.e 0) |
001760-24-3 |
N-(3-(trimethoxysilyl)propyl)ethylenediamine |
No |
39% |
Annex V C4-A |
1a |
2 |
None |
reaction mix (reaction mass of 6 benzylated amine silanes) |
No |
29 and 17% |
OECD 301B |
1a |
|
149048-48-6 |
1,3-Benzenedimethanamine, reaction products with 3-chloropropyltrimethoxysilane |
No |
19% (BOD); 20% (TOC) |
OECD 301C |
1a |
-1 (i.e 0) |
082985-35-1 |
Bis(trimethoxysilylpropyl)amine |
No |
11-20% |
OECD 301D |
1a |
-30 (i.e 0) |
References:
OECD (2004a): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1.
OECD (2004b): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 19-22 October 2004, Ethanol, CAS 64-17-5.
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