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Short-term toxicity to aquatic invertebrates

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Description of key information

Short-term toxicity to invertebrates: 48 hour EC50 >100 mg/l (nominal) (highest concentration tested) (EU method C.2), read-across from a structurally related substance, 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0). The EC50 is equivalent to >83 mg/l when expressed in terms of the silanol hydrolysis product.

Key value for chemical safety assessment

Additional information

There are no reliable short-term invertebrate toxicity data available for 3-[tris(acetoxy)silyl]propyl methacrylate (CAS 51772-85-1), therefore good quality data for the structurally-related substance, 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0), have been read across. Both substances share the same silanol hydrolysis product, 3-(trihydroxysilyl)propyl methacrylate. The other hydrolysis products are acetic acid and methanol, respectively.

A 48 hour EC50 value of >100 mg/l and a NOEC of ≥100 mg/l (nominal) (highest concentration tested) have been determined for the effects of the structurally-related substance, 3-trimethoxysilylpropyl methacrylate (CAS 2530-85-0) on mobility of Daphnia magna. This supported by a second test with EC50 of >876 mg/l and NOEC of ≥876 mg/l (highest concentration tested). In view of the exposure regime it is likely that the test organisms were exposed primarily to the hydrolysis products of the substance. The results may be expressed in terms of concentration of the hydrolysis product, 3-(trihydroxysilyl)propyl methacrylate, by applying a molecular weight correction: (MW of silanol = 206.27 / MW of parent = 248.35) * 100 mg/l = 83 mg/l.

Refer to the discussion in the Section 6 endpoint summary (Section 7.0 of CSR) for further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.