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EC number: 231-640-0 | CAS number: 7665-72-7
In the key study for acute oral toxicity study conducted with the target substance tert-butyl glycidyl ether the oral LD50 was determined to be 2000 mg/kg bw. Based on this result classification as Acute Tox 4, H302 is warranted. That classification for Acute Oral Toxicity is warranted is further supported by an acute oral toxicity study conducted with the structural analogue n-butyl glycidyl ether. The oral LD50 obtained from an acute oral toxicity study in mice treated with this read-across partner was 1530 mg/kg bw.
In an acute inhalation toxicity study five female Sprague Dawley rats were whole-body exposed for 7 hours to a vapour concentration of 17.72 mg/L of the target substance. No adverse signs of toxicity were observed. Based on the results the LD0 can be considered to be 17.72 mg/L and in accordance with the CLP regulation 1272/2008 no classification for acute inhalation toxicity is warranted.
In an acute oral toxicity study conducted equivalent to OECD TG 401, the target substance (99% purity) was orally administered to 2 male rats per dose group comprising of concentrations 126, 252, 500, 1000 and 2000 mg/kg bw. The animals were observed for 14 days. Observations were made at frequent intervals to check the body weights. The body weights and the pathological observations had no treatment related effects and no mortality was observed up to 1000 mg/kg bw. One out of two rats treated with 2000 mg/kg bw died. Hence, according to this study, it can be concluded that the LD50 of the substance is 2000 mg/kg bw.
In an acute inhalation toxicity study, five female Sprague Dawley rats were exposed whole-body to vapour concentrations of 17.72 mg/L and 86.02 mg/L of t-Butylglycidyl ether monomer for 7 hours. At a test item concentration of 17.72 mg/L, no treatment related effects were observed. However, at a test item concentration of 86.02 mg/L, four out of five rats died. Hence, it can be concluded that the test material was well tolerated up to 17.72 mg/L (LC0) without showing any mortality and classification for acute inhalation toxicity is not warranted.
Based on the available results, classification for acute oral toxicity is warranted (Acute Tox 4, H302). Based on the results from an acute inhalation toxicity study no classification is warranted for acute inhalation toxicity.
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