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Physical & Chemical properties

Melting point / freezing point

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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 September - 17 December 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as stated in study reports): JNJ-4508530-AAA (T002707)
- Physical state: solid (powder)
- Appearance: white, beige powder
Specific details on test material used for the study:
Batch n°: I15BB0573
Analytical purity: > 97.0%
Expiration date: 08 February 2017
Storage condition: at room temperature

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
221.2 °C
Atm. press.:
1 013.25 hPa
Decomposition:
yes
Remarks:
Reaction and/or decomposition was observed during and directly after melting.
Decomp. temp.:
>= 221.2 °C

Any other information on results incl. tables

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly at 225°C. At 343°C the sample weight has decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: white, beige). The change of the colour indicated reaction and/or decomposition of the test item.

Main tests

In order to determine the melting more precisely, the DSC curve with a heating rate of 20°C/min showed an endothermic peak followed by an exothermic peak between 200°C and 275°C. The extrapolated onset temperature of the endothermic peak was 221.12°C. The effect was most likely obtained due to melting (endothermic peak) and reaction and/or decomposition (exothermic peak). After the experiment, a yellow molten residue remained. To investigate the melting peak between 200°C and 275°C, a repeated heating cycle was applied. The extrapolated onset temperature of the melting peak was 221.23°C. The melting temperature of T002707 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 221.2°C (494.3K).

Applicant's summary and conclusion

Conclusions:
The melting temperature of JNJ-4508530-AAA (T002707) was determined at 221.2°C (494.3K) by using DSC. Reaction and/or decomposition of JNJ-4508530-AAA (T002707) was observed during DSC experiments during and directly after melting.