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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report Date:
2003

Materials and methods

Principles of method if other than guideline:
An excess of product is shaken with solvent during 24 hours at 20 deg C. After filtration the concentration in solution is determined with spectrometry.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as stated in study reports): JNJ-4508530-AAA (T002707)
- Physical state: solid (powder)
- Appearance: white, beige powder

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
methanol
Solubility:
43 g/L
Temp.:
20 °C
Medium:
ethanol
Solubility:
17 g/L
Temp.:
20 °C
Medium:
other: 2-propanol
Solubility:
8.3 g/L
Temp.:
20 °C
Medium:
other: 2-propanone
Solubility:
11 g/L
Temp.:
20 °C
Medium:
other: N,N-dimethylacetamide
Solubility:
35 g/L
Temp.:
20 °C
Medium:
dimethylformamide
Solubility:
> 200 g/L
Temp.:
20 °C
Medium:
other: acetic acid
Solubility:
> 200 g/L
Temp.:
20 °C

Applicant's summary and conclusion