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Physical & Chemical properties

Partition coefficient

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Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08 August 2017 - 19 February 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Version / remarks:
March 23 2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.23 Partition Coefficient (1-Octanol/Water): Slow-Stirring Method
Version / remarks:
March 04 2016
Deviations:
no
GLP compliance:
yes
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Analytical method:
other: UPLC-MS/MS
Key result
Type:
log Pow
Partition coefficient:
6
Temp.:
25 °C
pH:
7
Remarks on result:
other: Mean value

Table 1 Main study - Powof the test item

Vessel

Sampling point

Date and time of sampling

Analysed concentration

Pow

 Log Pow

 

1-octanol
[g/L]

water
[g/L]

Rec

[%]

 

Individual

Mean1

 

 

 

 

 

 

 

 

 

1

1

05-Feb-2018 08:15

94.7

5.95 x 10-5

107

1.6 x 106

6.2

6.2

 

2

05-Feb-2018 16:05

95.2

5.97 x 10-5

107

1.6 x 106

6.2

 

 

3

06-Feb-2018 09:12

79.5

5.54 x 10-5

90

1.4 x 106

6.2

 

 

4

06-Feb-2018 14:36

82.2

6.28 x 10-5

93

1.3 x 106

6.1

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2

1

05-Feb-2018 08:15

99.7

6.07 x 10-5

113

1.6 x 106

6.2

6.2

 

2

05-Feb-2018 16:05

99.6

6.28 x 10-5

112

1.6 x 106

6.2

 

 

3

06-Feb-2018 09:12

84.4

5.69 x 10-5

95

1.5 x 106

6.2

 

 

4

06-Feb-2018 14:36

93.1

6.37 x 10-5

105

1.5 x 106

6.2

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

3

1

05-Feb-2018 08:15

95.4

1.64 x 10-4

108

5.8 x 105

5.8

5.8

 

2

05-Feb-2018 16:05

102

1.66 x 10-4

115

6.1 x 105

5.8

 

 

3

06-Feb-2018 09:12

92.0

1.57 x 10-4

104

5.9 x 105

5.8

 

 

4

06-Feb-2018 14:36

85.6

1.60 x 10-4

97

5.3 x 105

5.7

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Mean log Pow 1

6.0

 

 

 

 

 

Mean Pow 1

1.0 x 106

 

 

 

 

 

Average sigma log Pow 1

0.146

 

 

 

 

 

 

 

 

 

 

 

 

1      Calculated using the first four measurements

Conclusions:
The mean log Pow of the test item was 6.0.
Executive summary:

Volic (2018) is a GLP-compliant study following OECD guideline 123, slow-stirring method. The chosen method is suitable for the test item, and preliminary and feasibility studies were conducted prior to the main test. The analytical method was validated before the study. The study is therefore considered to be reliable without restrictions (Klimisch 1). The mean log Pow of the test item was 6.0.

Description of key information

The mean log Pow of the test item was 6.0.

Key value for chemical safety assessment

Log Kow (Log Pow):
6
at the temperature of:
25 °C

Additional information

Volic (2018) is a GLP-compliant study following OECD guideline 123, slow-stirring method. The chosen method is suitable for the test item, and preliminary and feasibility studies were conducted prior to the main test. The analytical method was validated before the study. The study is therefore considered to be reliable without restrictions (Klimisch 1). The mean log Pow of the test item was 6.0.