Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-474-9 | CAS number: 107-22-2
Endpoint summary
Administrative data
Description of key information
By oral route the key study is the study conducted by Société Française Hoechst (1987) according to OECD guideline 407 on rats. A no effect level of 100 mg/kg bw/d was established for glyoxal 40% (i.e. 40 mg/kg bw/d related to the active ingredient). This value is supported by the studies by Ueno (1991a, b) on rats which obtained a LOEL of 107 mg/kg bw/d related to pure glyoxal, as well as by the study from Union Carbide (1966) on dogs which derived a NOEL of 115 mg/kg bw/d related to pure glyoxal. In a subacute inhalation study on rats for 29 days, a NOEL of 0.4 mg/m3 was derived for local effects and of > 10 mg/m3 for the systemic toxicity (40%glyoxal). No dermal repeated toxicity studies have been performed.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
