(2-hydroxypropyl)trimethylammonium 2-ethylhexanoate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

One group of ten albino rabbits weighing between 2.5 and 3.5 kg each were employed in this study.
All animals had their backs clipped free of hair 24 hours prior to testing. One half of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied. 2.0 g/kg dosage was administered.
All rabbits were weighed and the correct amunt of experimental material was applied to the back of each animal. These treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal.
The dressings were removed after twenty-four hours and any excess material was removed and the approximate amount remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities.

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

(2-hydroxypropyl)trimethylammonium 2-ethylhexanoate

EC Number:

263-502-0

EC Name:

(2-hydroxypropyl)trimethylammonium 2-ethylhexanoate

Cas Number:

62314-22-1

Molecular formula:

C8H15O2.C6H16NO

IUPAC Name:

(2-hydroxypropyl)trimethylammonium 2-ethylhexanoate

Constituent 2

Reference substance name:

Ethane-1,2-diol

EC Number:

203-473-3

EC Name:

Ethane-1,2-diol

Cas Number:

107-21-1

Molecular formula:

C2H6O2

IUPAC Name:

ethylene glycol

Test material form:

liquid: viscous

Test animals

Species:

rabbit

Sex:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

All animals had their backs clipped free of hair 24 hours prior to testing. One half of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied. 2.0 g/kg dosage was administered.

Duration of exposure:

24 h

Doses:

2 g/kg b.w.

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

One group of ten albino rabbits weighing between 2.5 and 3.5 kg each were employed in this study.
All animals had their backs clipped free of hair 24 hours prior to testing. One half of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied. 2.0 g/kg dosage was administered.
All rabbits were weighed and the correct amunt of experimental material was applied to the back of each animal. These treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal.
The dressings were removed after twenty-four hours and any excess material was removed and the approximate amount remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality observed

Clinical signs:

other: Not available

Gross pathology:

Not available

Other findings:

Not available

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

Hydroxypropyl, N-2-, N,N,N-trimethylammonium 2-ethylhexanoate 75% in Ethyleneglycol was tested for acute dermal toxicity on rabbits. Test determined LD50 > 2 000 mg/kg b.w.

Executive summary:

Hydroxypropyl, N-2-, N,N,N-trimethylammonium 2-ethylhexanoate 75% in Ethyleneglycol was tested for acute dermal toxicity on rabbits. Test determined LD50 > 2 000 mg/kg b.w.