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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: QSAR prediction
Title:
Unnamed
Year:
2017

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
(Q)SAR was applied
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl acetate
EC Number:
605-722-5
Cas Number:
1743-60-8
Molecular formula:
C20H26O3
IUPAC Name:
(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl acetate
Test material form:
solid: crystalline

Results and discussion

Test resultsopen allclose all
Key result
Species / strain:
S. typhimurium TA 97
Metabolic activation:
with and without
Key result
Species / strain:
S. typhimurium TA 100
Metabolic activation:
with and without
Key result
Species / strain:
S. typhimurium TA 1535
Metabolic activation:
with and without
Key result
Species / strain:
S. typhimurium TA 1537
Metabolic activation:
with and without
Key result
Species / strain:
E. coli WP2
Metabolic activation:
with and without
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion