Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, B.3
GLP compliance:
yes
Limit test:
yes

Test animals

Species:
other: rat, Sprague-Dawley HSD:SD

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: None
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No deaths occurred. Two females showed loss of body weight
during the first week of the study. Two other animals showed
a slight loss of body weight at the end of the study.
Development of body weight was not impaired in male animals.

No symptoms were observed in male animals. Female animals
showed (starting on day 2) squatting posture, stilted and
uncoordinated gait, ataxia, drawn in flanks, irregular
respirations, hypoactivity, bristling coat, stupor,
mydriasis, straddled hind limbs and trembling.


From day 10 until the end of the study no symptoms were
observed.
Gross pathology:
Effects on organs:
Animals killed at the end of the observation period showed
no macroscopically visible changes.
Other findings:
Signs of toxicity (local):
The skin of all animals showed no signs of irritation.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU

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