Registration Dossier
Registration Dossier
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EC number: 263-503-6 | CAS number: 62314-25-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 18, 1976 - December 29, 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- A group of ten male albino rats was used in this study. The rats were placed in a 70 liter all glass exposure chamber and exposed to a saturated atmosphere of the test material in air for one hour.
The material was administered as an aerosol with particles 3-5 microns in diameter.
The rate of flow was 10.0 liters per minute at a temperature of 71°f (21.67°c).
The air was passed through a desicant prior to being passed through the test material.
By differential weighing it was calculated that the rats were subjected t o a concentration of 7.5 m g / liter during the exposure period. This is an average value over the one hour period. - GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- (2-hydroxypropyl)trimethylammonium formate
- EC Number:
- 263-503-6
- EC Name:
- (2-hydroxypropyl)trimethylammonium formate
- Cas Number:
- 62314-25-4
- Molecular formula:
- C6H16NO.CHO2
- IUPAC Name:
- (2-hydroxypropyl)trimethylammonium formate
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Remarks:
- albino
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- > 3 - <= 5 µm
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 7.5 mg / liter
- No. of animals per sex per dose:
- 10 males in one dose group
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 7.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- No mortalities observed after 14 days
- Clinical signs:
- other: No behavioural abnormalities observed.
- Body weight:
- Not recorded
- Gross pathology:
- Gross parthologic examonation of all animal revealed nothing remarkable.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study the LC50 for Dabco TMR-2 was found to be greater than 7.5 m g / liter .
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