Registration Dossier

Administrative data

Endpoint:
specific investigations: other studies
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Principles of method if other than guideline:
Test procedure:
Annex V

Results and discussion

Details on results:
Sex Dose(mg/kg) No. of animals Perfusion time (hrs)


M 0 5 2

M 0 5 16

M 666.7 4 2

M 666.7 4 16

M 2000 4 2

M 2000 4 16


The maximum recommended dose of 2000mg/kg was used in this
study. Clinical signs of hunched posture, lethargy, ataxia,
splayed gait and tip toe gait where also seen at this dose
level.


Result = Negative

Applicant's summary and conclusion