1,2,4-Benzenetricarboxylic acid, mixed branched tridecyl and isodecyl esters

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian germ cell study: cytogenicity / chromosome aberration

Remarks:

Type of genotoxicity: chromosome aberration

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

1983

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: As reported in secondary literature source.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1983

Reference 2

Reference Type:

secondary source

Title:

TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE

Author:

OECD SIDS

Year:

2002

Bibliographic source:

SIDS Initial Assessment Report for Siam 14: TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Dominant lethal assay.

GLP compliance:

not specified

Type of assay:

rodent dominant lethal assay

Test material

Test material information

Constituent 1

Reference substance name:

tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

IUPAC Name:

tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate

Constituent 2

Reference substance name:

Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

EC Number:

222-020-0

EC Name:

Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Cas Number:

3319-31-1

Molecular formula:

C33H54O6

IUPAC Name:

tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Test animals

Species:

mouse

Strain:

Strain A

Sex:

male

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

other: no data

Vehicle:

no data

Details on exposure:

Guaranteed fertile males were treated by an unspecified route. This very brief account gives no further details.

Duration of treatment / exposure:

no data

Frequency of treatment:

no data

Post exposure period:

no data

Doses / concentrations

Remarks:

Doses / Concentrations:
ca. 1400 mg/kg bw (possibly per day)
Basis:
no data

Positive control(s):

METEPA, probably tris(1-(2-methyl)aziridinyl) phosphine oxide

Results and discussion

Test results

Sex:

male

Genotoxicity:

negative

Toxicity:

not specified

Vehicle controls validity:

not specified

Negative controls validity:

not specified

Positive controls validity:

valid

Additional information on results:

TOTM was not mutagenic when compared with the positive control (METEPA, probably tris(1-(2-methyl)aziridinyl) phosphine oxide); results
with METEPA confirmed the validity of the system.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): negative
Based on the data reported, the test material was not clastogenic.

Classification as clastogenic is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.

Executive summary:

Based on the data reported, the test material was not clastogenic.

Classification as clastogenic is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.