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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1983
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: As reported in secondary literature source.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1983
Reference Type:
secondary source
Title:
TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE
Author:
OECD SIDS
Year:
2002
Bibliographic source:
SIDS Initial Assessment Report for Siam 14: TRIS(2-ETHYLHEXYL)BENZENE-1,2,4-TRICARBOXYLATE

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Dominant lethal assay.
GLP compliance:
not specified
Type of assay:
rodent dominant lethal assay

Test material

Constituent 1
Reference substance name:
tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
IUPAC Name:
tris(2-ethylhexyl)benzene-1,2,4-tricarboxylate
Constituent 2
Chemical structure
Reference substance name:
Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
EC Number:
222-020-0
EC Name:
Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
Cas Number:
3319-31-1
Molecular formula:
C33H54O6
IUPAC Name:
tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Test animals

Species:
mouse
Strain:
Strain A
Sex:
male
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
other: no data
Vehicle:
no data
Details on exposure:
Guaranteed fertile males were treated by an unspecified route. This very brief account gives no further details.
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
ca. 1400 mg/kg bw (possibly per day)
Basis:
no data
Positive control(s):
METEPA, probably tris(1-(2-methyl)aziridinyl) phosphine oxide

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative
Toxicity:
not specified
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
valid
Additional information on results:
TOTM was not mutagenic when compared with the positive control (METEPA, probably tris(1-(2-methyl)aziridinyl) phosphine oxide); results
with METEPA confirmed the validity of the system.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Based on the data reported, the test material was not clastogenic.

Classification as clastogenic is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Executive summary:

Based on the data reported, the test material was not clastogenic.

Classification as clastogenic is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations.