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EC number: 615-086-0 | CAS number: 70225-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Long-term toxicity to fish - read across data
Read-across results of a 14-day study with surrogate, tri-2-ethylhexyl trimellitate (TOTM) indicate that the submission substance is not expected to produce chronic toxicity to fish at its maximum water solubility limits.
Key value for chemical safety assessment
Additional information
Chronic fish toxicity data were not available for the submission substance, CAS No. 70225-05-7. However, there are sufficient read-across chronic toxicity fish data reported for tri-2-ethylhexyl trimellitate (TOTM)(CAS 3319-31-1), a related trimellitate surrogate, to help assess the long-term toxicity potential in fish for the submission substance.
A chronic 14-day study has been carried out in medaka with tri-2-ethylhexyl trimellitate (TOTM) at exposure loading levels of 18.8, 37.5 and 75 mg/L. Results indicated that TOTM did not cause any mortality in medaka in the prolonged fish toxicity test. The 14-day LL50 was determined to be >75 mg/L and the 14-day NOEL was determined to be > 75 mg/L, which are orders of magnitude above the maximal water solubility of TOTM. These findings indicate that tri-2-ethylhexyl trimellitate (CAS No. 3319-31-1) is not expected to cause any chronic toxicity to fish at its maximum water solubility limit.
Based on the read-across chronic non-toxicity findings for the surrogate trimellitate and owing to their chemical similarity, the submission substance, CAS No. 70225-05-7, also would not be expected to be cause any chronic toxicity to fish at its maximal water solubility limit.
The findings are consistent with the structurally similarity and close physicochemical characteristics (e.g., low water solubility) between these two trimellitate materials. The absence of any chronic toxicity may be due in part to their low water solubility, resulting in low exposure potential in the aqueous compartment as well as to the ability of organisms to metabolize or biodegrade the test materials.
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