Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

Link to relevant study record(s)

biodegradation in water: ready biodegradability
Type of information:
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Internationally accepted method, EPI-Suite, EPA (USA)
Justification for type of information:
See attached the QMRF and QPRF for the QSAR model
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
Howard, P.H., Boethling, R.S., Stiteler, W.M., Meylan, W.M., Hueber, A.E., Beauman, J.A., Larosche, M.E. 1992. Predictive model for aerobic biodegradability developed from a file of evaluated biodegradation data. Environ. Toxicol. Chem. 11:593-603.
Specific details on test material used for the study:
Key result
probability of ready biodegradability (QSAR/QSPR)
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction

Biowin1 (Linear Model) : 0.8738

Biowin2 (Non-Linear Model) : 0.8545

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model): 3.1227 (weeks)

Biowin4 (Primary Survey Model) : 3.9726 (days)

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model) : 0.3882

Biowin6 (MITI Non-Linear Model): 0.2206

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): 0.6746

Ready Biodegradability Prediction: NO

Validity criteria fulfilled:
not applicable
Interpretation of results:
not readily biodegradable
The test substance was predicted to be not readily biodegradable (EPI-Suite, BIOWIN v4.10).
Executive summary:

The test substance was predicted to be not readily biodegradable (EPI-Suite, BIOWIN v4.10).

Description of key information

Key Study. Data from EPI-Suite, EPA (USA) / BIOWIN v4.10 calculation method. The test substance was predicted to be not readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information