(+)-L-arginine hydrochloride

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Remarks:

Internationally accepted method, EPI-Suite, EPA (USA)

Justification for type of information:

See attached the QMRF and QPRF for the QSAR model

Guideline:

other: REACH Guidance on QSARs R.6

Principles of method if other than guideline:

Howard, P.H., Boethling, R.S., Stiteler, W.M., Meylan, W.M., Hueber, A.E., Beauman, J.A., Larosche, M.E. 1992. Predictive model for aerobic biodegradability developed from a file of evaluated biodegradation data. Environ. Toxicol. Chem. 11:593-603.

Specific details on test material used for the study:

SMILES: OC(=O)C(N)CCCNC(N)=[N+](H)H.[Cl-]

Key result

Parameter:

probability of ready biodegradability (QSAR/QSPR)

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Biowin1 (Linear Model) : 0.8738

Biowin2 (Non-Linear Model) : 0.8545

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model): 3.1227 (weeks)

Biowin4 (Primary Survey Model) : 3.9726 (days)

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model) : 0.3882

Biowin6 (MITI Non-Linear Model): 0.2206

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): 0.6746

Ready Biodegradability Prediction: NO

Validity criteria fulfilled:

not applicable

Interpretation of results:

not readily biodegradable

Conclusions:

The test substance was predicted to be not readily biodegradable (EPI-Suite, BIOWIN v4.10).

Executive summary:

The test substance was predicted to be not readily biodegradable (EPI-Suite, BIOWIN v4.10).

Description of key information

Key Study. Data from EPI-Suite, EPA (USA) / BIOWIN v4.10 calculation method. The test substance was predicted to be not readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:

under test conditions no biodegradation observed