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EC number: 260-789-4 | CAS number: 57526-50-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Initiation: March 01, 1983 - Termination: March 08,1983.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- No data about purity of the substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- May 12, 1981
- GLP compliance:
- no
Test material
- Reference substance name:
- Octahydro-4,7-methano-1H-indene-5-methanol
- EC Number:
- 260-789-4
- EC Name:
- Octahydro-4,7-methano-1H-indene-5-methanol
- Cas Number:
- 57526-50-8
- Molecular formula:
- C11H18O
- IUPAC Name:
- {tricyclo[5.2.1.0²,⁶]decan-8-yl}methanol
- Test material form:
- liquid
- Details on test material:
- Hoechst 1983
Constituent 1
- Specific details on test material used for the study:
- No information on purity. However, as it is stated in the section 13, the substance and its composition have remained essentially the same over the last decades.
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Remarks:
- Albino Himalayan (SPF Wiga)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Weight at study initiation: 1.7 - 2.2 kg (3 animals)
- Housing: individual cages in fully air-conditioned rooms
- Diet (e.g. ad libitum): feed for breeding rabbits ERKA Z 6000, ad libitum
- Water (e.g. ad libitum): deionized chlorinated water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 °C
- Humidity (%): 50 +/- 20 %
- Photoperiod (hrs dark / hrs light): 12 hours per day
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Remarks:
- 24 hours before test initiation
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- 0,5 mL
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- Exposure time of 4 hours. After the exposure the remaining substance was carefully removed from the skin.
- Observation period:
- First assessment 30-60 minutes after the treatment. Then after 24, 48 and 72 hours and after 7 days.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal / lateral part.
- Coverage / Type of wrap: substance placed on the cellulose part of a plaster (specially designed from Baiserdorf AG, Hamburg, 2.5 cm x 2.5 cm).
REMOVAL OF TEST SUBSTANCE
- After the exposure the remaining substance was carefully removed from the skin.
OBSERVATION TIME POINTS
30-60 minutes, 24 hours, 48 hours, 72 hours and 7 days after the removal of the plaster.
SCORING SYSTEM:
- Method of calculation: numerical assessment for the formation of erythema and oedema according to the OECD guideline (Draize) and with the labelling of the respective observations.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- mean value of all animals and all time periods
- Time point:
- other: mean value from all time points between 30-60 minutes and 72 hours after exposure
- Score:
- 2.8
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks:
- but decrease of effect and only grade 1 observed on Day 7
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test item caused slight irritation under the conditions of this test.
- Executive summary:
Based on an exposure of 4 hours of an undiluted solution of the test item, a PDII of 2.8 has been determined. It is calculated from the sum of the scoring for erytheme and oedeme observations (12 according to the grading of skin reactions of the OECD guideline) divided by a factor of 12 (number of animals and number of time points 3x4).
The test item caused well defined erythema and slight oedema in all rabbits within 24 hours after removal of the patch. The effect persisted until 72 hours (mean erythema scores for the individual animals after 24, 48 and 72 hours: 2.3, 2.0, 2.3;
mean edema scores for the individual animals after 24, 48 and 72 hours: 1.0, 1.0, 1.3 ) and subsided within 7 days except in one animal, which still showed slight erythema after 7 days (score 1).
Dry, chapped and squamos skin was found in 1 of 3 animals 72 hours after removal of the patch and in all animals after 7 days.
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