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EC number: 226-901-0 | CAS number: 5538-94-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not spcified.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- According to 'Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics' published by the Association of Food and Drugs Officials of the United States.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyldioctylammonium chloride
- EC Number:
- 226-901-0
- EC Name:
- Dimethyldioctylammonium chloride
- Cas Number:
- 5538-94-3
- Molecular formula:
- C18H40NCl
- IUPAC Name:
- dimethyldioctylazanium chloride
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Quat LF-50
50% active, but the test concentrations employed were based on 100% actives.
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- The substance (4 ml) was applied daily to the skin to cover 10% of the body surface for 20 consecutive days.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Twenty days of repeated daily applications.
- Frequency of treatment:
- Daily.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.002 other: based on 100% actives
- Dose / conc.:
- 0.001 other: based on 100% actives
- Dose / conc.:
- 0 other: based on 100% actives
- No. of animals per sex per dose:
- Two/sex/dose
- Control animals:
- yes, concurrent no treatment
- Positive control:
- None.
Examinations
- Observations and examinations performed and frequency:
- Food, bodyweight, fluid intake, excretions and behaviour and appearance were oberved. Blood and urine studies were performed at the begining of the test, at the 20 day interval and prior to autopsy.
- Sacrifice and pathology:
- Following sacrifice tissues were collected for gross and histological examinations. The tissues collected were skin, thyroid, lungs, heart, liver, spleen, adrenal, kidney, ovary, uterus and testes. Histopathology was examined in skin, thyroid, liver, lung, spleen, heart, adrenal, testes, ovary and fallopian tubes.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- no effects observed
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- no effects observed
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 0.002 other: %
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- behaviour (functional findings)
- body weight and weight gain
- clinical signs
- dermal irritation
- gross pathology
- haematology
- histopathology: non-neoplastic
- mortality
- urinalysis
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Applicant's summary and conclusion
- Conclusions:
- The substance caused no significant toxicity or pathology in rabbits following daily dermal exposure to concentrations of 0.002, 0.001 and 0.00025%.
- Executive summary:
In a subacute toxicity study the substance was administered to male and female (2/sex/dose) rabbits (strain unspecified) by dermal application levels of 0.00025, 0.001 and 0.002% of a 100% active solution. At no time during the study were there any aberrations in food or fluid intake, excretions, appearance or behaviour noted. All blood and urine findings were within normal limits. Gross and histopathological examinations of significant organs and tissues were all unremarkable. The NOEL is identified to 0.002%.
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