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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Fragrance material review on fenchyl alcohol
Author:
Bhatia S P
Year:
2008
Bibliographic source:
Food and Chemical Toxicology, 46 (2008), pp 157-159

Materials and methods

Principles of method if other than guideline:
No data on test method
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3-dimethyl-8,9-dinorbornan-2-ol
EC Number:
216-639-5
EC Name:
3,3-dimethyl-8,9-dinorbornan-2-ol
Cas Number:
1632-73-1
Molecular formula:
C10H18O
IUPAC Name:
1,3,3-trimethylbicyclo[2.2.1]heptan-2-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
2050, 2560, 3200, 4000 and 5000 mg/kg bw.
No. of animals per sex per dose:
2 animals for doses of 2050, 2560 and 4000 mg/kg bw
3 animals for dose of 3200 mg/kg bw
5 animals for dose of 5000 mg/kg bw
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 050 mg/kg bw
Based on:
test mat.
Mortality:
All deaths occurred between days 1 and 3.
At 2050 and 2560 mg/kg bw, 1/2 animals died; 3/3 animals died at 3200 mg/kg bw; 2/2 animals died at 4000 mg/kg bw and 5/5 animals died at 5000 mg/kg bw.
Clinical signs:
other: Clinical signs included lethargy, ataxia, tearing, comatose and flaccid (no further details were reported).

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The acute oral LD50 value of the test substance was found to be 2050 mg/kg bw in rats.
Executive summary:

The acute oral toxicity of the test item was evaluated in rats. The test substance was administered at dose levels of 2050, 2560, 3200, 4000, and 5000 mg/kg body weight. Mortality and clinical observations were analyzed for 14 days after exposure. All deaths occurred between days 1 and 3. At 2050 and 2560 mg/kg bw, 1/2 animals died; 3/3 animals died at 3200 mg/kg bw; 2/2 animals died at 4000 mg/kg bw and 5/5 animals died at 5000 mg/kg bw. Clinical signs included lethargy, ataxia, tearing, comatose and flaccid. The acute oral LD50 value of the test substance was determined to be 2050 mg/kg bw.