Phenylacetaldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Limited documentation. No information on analytical purity of test substance given.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

Limited documentation. No information on analytical purity of test substance given.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Phenylacetaldehyde

EC Number:

204-574-5

EC Name:

Phenylacetaldehyde

Cas Number:

122-78-1

Molecular formula:

C8H8O

IUPAC Name:

2-phenylacetaldehyde

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

840, 2050, 4000, 5000 and 6250 mg/kg bw

No. of animals per sex per dose:

10 in total

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

1 550 mg/kg bw

Based on:

test mat.

Mortality:

840 mg/kg bw: 3/10 animals died
2050 mg/kg bw: 5/10 animals died
4000 mg/kg bw: 10/10 animals died
5000 mg/kg bw: 6/10 animals died
6250 mg/kg bw: 8/10 animals died

Clinical signs:

other: 840 mg/kg bw: No clinical signs were observed within study period. 2050 mg/kg bw: lethargy and flaccidity 4000 mg/kg bw: lethargy, ptosis, piloerection and convulsions in one animal 5000 mg/kg bw: lethargy, ptosis, piloerection 6250 mg/kg bw: lethargy,

Gross pathology:

Gross pathology of animals revealed red / yellow stomach and intestine, yellow exudate of nose and mouth in one animal, yellow coloured portions of interior abdominal wall, blood in lumen of intestine, red small intestine, blood in bladder, dark liver, kidney and lungs and signs of cannibalization.

Any other information on results incl. tables

Table 1. Results of the acute oral toxicity study.

Dose level (mg/kg bw)	Mortalities
	n
840	3/10
2050	5/10
4000	10/10
5000	6/10
6250	8/10

 

Table 2. Clinical signs found in necropsy.

Clinical signs	No of rats with clinical sign at respective dose [mg/kg bw]
	840	2050	4000	5000	6250
Red stomach and intestine	1	0	1	2	0
Yellow stomach and intestine	0	4	5	4	7
Dark liver	0	3	2	3	7
Yellow exudate of nose and mouth	1	4	8	2	7
Yellow portions of interior abdominal wall	0	1	3	1	1
Blood in lumen of intestine	0	0	1	1	1
Red small intestine	0	2	3	0	6
Blood in bladder	0	1	0	0	1
Dark kidneys	0	0	0	0	5
Dark lungs	0	2	3	0	1
Signs of cannibalization	1	0	0	0	0

 

Applicant's summary and conclusion

Interpretation of results:

other: Acute Tox. 4 according to Regulation (EC) No 1272/2008

Conclusions:

In this acute oral toxicity study a LD50 value of 1550 mg/kg bw was derived in rats.