3-((3,4-dicyanophenyl)sulfonyl)-N-(2-hydroxypropyl)propane-1-sulfonamide

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental phase: 03 October 2017 to 25 March 2018.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Deviations:

yes

Remarks:

The study plan did not have sufficient information on the test substance item for identification purposes and further test item information was included in the report. This deviation is not considered to have had any impact on the integrity of the study.

Qualifier:

according to guideline

Guideline:

EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))

Deviations:

yes

Remarks:

The study plan did not have sufficient information on the test substance item for identification purposes and further test item information was included in the report. This deviation is not considered to have had any impact on the integrity of the study.

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC estimation method

Media:

other: HPLC column containing lipophilic and polar moieties

Details on study design: HPLC method:

EQUIPMENT
HPLC system : Agilent Technologies 1200
Detector type: Variable wavelength (VW)
Column : XSelect CN 5µm (150 x 4.6 mm id)
Column temperature : 30 °C
Flow rate : 1 ml/min
Injection volume : 10µl
VW detector wavelength: 210 nm

PREPARATION OF SAMPLE SOLUTION
Test substance (0.1053g) was diluted to 100 mL with methanol to give a concentration of 1.05 g/L.

MOBILE PHASES
- Type: methanol:purified water (55:45 v/v)
- pH: 6.3

DETERMINATION OF DEAD TIME
- Method: dead time determined by measuring the retention time of 0.664 g/L formamide (purity 99.6%) in methanol.

REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Atrazine, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, α-Endosufan, Phenanthrene, Diclofop-methyl, DDT

Key result

Type:

Koc

Value:

17.1 dimensionless

Key result

Type:

log Koc

Value:

1.23 dimensionless

The retention times, capcity factor and Log10 Koc value determined for the sample are shown in the following table:

Injection	Retention Time (mins)	Capacity Factor (K')	Log10 K'	Log10 Koc
1	2.833	0.438	-0.359	1.23
2	2.833	0.438	-0.359	1.23

Mean Log₁₀ Koc: 1.23

Adsorption coefficient: 17.1

Validity criteria fulfilled:

yes

Conclusions:

The adsorption coefficient (Koc) of the test item was determined to be 17.1 and the log10 Koc = 1.23. These values indicate that the mobility of the test susbtance will be classified as very high.

Executive summary:

Introduction

The Adsorption coefficient of the test substance was determined using the HPLC screening method, designed to be compatible with the following methods:

1) Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001

2) Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008

Method

The adsorption coefficient was estimated using a high performance liquid chromotography (HPLC).

Result and Conclusion

The adsorption coefficient (Koc) of the test item was determined to be 17.1 and the log10 Koc = 1.23.  These values indicate that the mobility of the test susbtance will be classified as very high.

Description of key information

Adsorption coefficient of the test substance.

Key value for chemical safety assessment

Koc at 20 °C:

17

Additional information

[LogKoc: 1.23]