Registration Dossier
Registration Dossier
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EC number: 204-498-2 | CAS number: 121-79-9
Endpoint summary
Administrative data
Description of key information
Propyl gallate has a log Kow of 1.8 and is not surface active, but may be ionisable at environmental pH 4-9. Therefore, the potential for bioaccumulation is not solely driven by lipophilicity.
To evaluate the potential for bioaccumulation in aquatic species, information on human toxicokinetics, metabolism and distribution is considered: While adsorption rates may be different (low in mice, high in rats), the substance is excreted after liver passage rats, releasing mainly gallic acid into the systemic circulation. In human plasma samples were not detected but in omentum samples. The metabolism of propyl gallate as well as the excretion was found to be fast in rats and rabbits after oral administration, with complete excretion of the original ester and gallic acid within 24 hours. In conclusion, propyl gallate has no potential for bioaccumulation in mammals.
Similar metabolism and excretion are anticipated after liver passage in fish. Analogously, no potential for bioaccumulation is expected in fish.
Additional information
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