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EC number: 208-100-8 | CAS number: 509-60-4
Pregnant Sprague-Dawley female rats were made tolerant to the test material by initiating s.c. injections of 2 mg/kg (base) of drug, twice daily, 30 hours after breeding and increasing the dosage to 15 mg/kg. Control nontolerant pregnant animals were treated in an identical manner except that they were injected with saline. Foetuses were removed by caesarean section at intervals of one-half to four hours after s.c. injection of 7 mg/kg (base) of H3- test material to the maternal rat on the 21st day of gestation. Free and conjugated-levels of test material were assessed in maternal and foetal tissues and plasma.
The larger dose of test material administered chronically reduces the number of litters and gain of maternal body weight but had no effect on the foetal body weight and the number of foetuses per litter.
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